Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chloramphenicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.90 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.90 |
| ▸ | RPS17 | P08708 | 1/20 | 0.90 |
| ▸ | RPSA | P08865 | 1/20 | 0.90 |
| ▸ | RPS2 | P15880 | 1/20 | 0.90 |
| ▸ | RPL35A | P18077 | 1/20 | 0.90 |
| ▸ | RPL7 | P18124 | 1/20 | 0.90 |
| ▸ | RPL17 | P18621 | 1/20 | 0.90 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.90 |
| ▸ | RPS3 | P23396 | 1/20 | 0.90 |
| ▸ | RPS12 | P25398 | 1/20 | 0.90 |
| ▸ | RPL13 | P26373 | 1/20 | 0.90 |
| ▸ | RPL10 | P27635 | 1/20 | 0.90 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloramphenicol SCHEMBL28181476 | 1.00 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL49057 | 1.00 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL16111 | 1.00 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL29557257 | 1.00 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL4295048 | 1.00 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL537158 | 1.00 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL11131056 | 0.99 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL41042 | 0.99 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL20531030 | 0.99 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL28607485 | 0.99 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10550384-B2 | Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-02-04 | — | — | US | claimed |
| US-20180127746-A1 | Production and Monitoring of Metabolites in Cells | UNITED STATES DEPARTMENT OF ENERGY | 2018-05-10 | — | — | US | claimed |
| US-11774442-B2 | Molecule sensor systems | ENEVOLV, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-11603528-B2 | Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-03-14 | — | — | US | disclosed |
| US-11365410-B2 | Production and monitoring of metabolites in cells | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2022-06-21 | — | — | US | disclosed |
| EP-3108003-B1 | DE NOVO DESIGN OF ALLOSTERIC PROTEINS | HARVARD COLLEGE (US) | 2022-02-09 | — | — | EP | disclosed |
| US-10920217-B2 | De novo design of allosteric proteins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2021-02-16 | — | — | US | disclosed |
| US-20200216835-A1 | Methods For Selecting Microbes From A Diverse Genetically Modified Library to Detect and Optimize the Production of Metabolites | U.S. DEPARTMENT OF ENERGY | 2020-07-09 | — | — | US | disclosed |
| US-20200123531-A1 | De Novo Design of Allosteric Proteins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-04-23 | — | — | US | disclosed |
| US-10550384-B2 | Methods for selecting microbes from a diverse genetically modified library to detect and optimize the production of metabolites | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2020-02-04 | — | — | US | disclosed |
| CN-110161099-A | Using titanium dioxide nano-rod composite material as the construction method of the electrochemical aptamer sensor of electrochemistry tracer | 河南大学 | 2019-08-23 | — | — | CN | disclosed |
| US-20170132358-A1 | De Novo Design of Allosteric Proteins | UNITED STATES DEPARTMENT OF ENERGY | 2017-05-11 | — | — | US | disclosed |
| US-20160017317-A1 | Methods For Selecting Microbes From A Diverse Genetically Modified Library to Detect and Optimize the Production of Metabolites | ENERGY, UNITED STATES DEPARTMENT OF | 2016-01-21 | — | — | US | disclosed |
| EP-2102363-A2 | ASSAYS FOR FUNGAL INFECTION | The University of Manchester (GB) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008063370-A9 | ASSAYS FOR FUNGAL INFECTION | UNIV MANCHESTER (GB) | 2008-07-31 | — | — | WO | disclosed |
| WO-2008063370-A2 | ASSAYS FOR FUNGAL INFECTION | THE UNIVERSITY OF MANCHESTER (GB) | 2008-05-29 | — | — | WO | disclosed |
| EP-0970065-A4 | ANTIBIOTICS AND PROCESS FOR PREPARATION | TRUETT WILLIAM L (US) | 2001-03-07 | — | — | EP | disclosed |
| EP-0970065-A1 | ANTIBIOTICS AND PROCESS FOR PREPARATION | Truett, William L. (US) | 2000-01-12 | — | — | EP | disclosed |
| WO-1999028308-A1 | ANTIBIOTICS AND PROCESS FOR PREPARATION | TRUETT WILLIAM L (US) | 1999-06-10 | — | — | WO | disclosed |
| US-5693791-A | PENICILLINS AND CEPHALOSPORINS LINKED TO METRONIDAZOLE TO PRODUCE ANTIBIOTICS WITH NEW PROPERTIES | TRUETT WILLIAM L (US) | 1997-12-02 | — | — | US | disclosed |