Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chloramphenicol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.97 |
| ▸ | MARS2 | Q96GW9 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.88 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.88 |
| ▸ | RPS17 | P08708 | 1/20 | 0.88 |
| ▸ | RPSA | P08865 | 1/20 | 0.88 |
| ▸ | RPS2 | P15880 | 1/20 | 0.88 |
| ▸ | RPL35A | P18077 | 1/20 | 0.88 |
| ▸ | RPL7 | P18124 | 1/20 | 0.88 |
| ▸ | RPL17 | P18621 | 1/20 | 0.88 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.88 |
| ▸ | RPS3 | P23396 | 1/20 | 0.88 |
| ▸ | RPS12 | P25398 | 1/20 | 0.88 |
| ▸ | RPL13 | P26373 | 1/20 | 0.88 |
| ▸ | RPL10 | P27635 | 1/20 | 0.88 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloramphenicol SCHEMBL28181476 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL4262903 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL16111 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL49057 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL4295048 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL29557257 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL537158 | 0.99 | LMNA (1.00) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL11131056 | 0.97 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL41042 | 0.97 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 | |
| Chloramphenicol SCHEMBL20531030 | 0.97 | LMNA (0.97) | LMNACYP3A4TSHRSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 260 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104237521-A | Three-in-one colloidal gold chromatographic test strip for detecting thiamphenicol, chloramphenicol and florfenicol and preparation method thereof | UNIV JIANGNAN | 2014-12-24 | — | — | CN | claimed |
| US-20240199733-A1 | Anti-IL-23 Antibodies | JANSSEN BIOTECH INC (US) | 2024-06-20 | — | — | US | disclosed |
| CN-117940182-A | Processing of injector device components through a syringe | W.L.戈尔及同仁股份有限公司 | 2024-04-26 | — | — | CN | disclosed |
| US-11939375-B2 | — | — | 2024-03-26 | — | — | US | disclosed |
| CN-110475545-B | Injectable and biodegradable polymeric formulations for the controlled release of bioactive agents | W.L.戈尔及同仁股份有限公司 | 2024-01-05 | — | — | CN | disclosed |
| CN-116457020-A | Formulations, methods and prefilled injection devices free of fatty acid particles | W.L.戈尔及同仁股份有限公司 | 2023-07-18 | — | — | CN | disclosed |
| US-20230071749-A1 | Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses | JANSSEN BIOTECH, INC. | 2023-03-09 | — | — | US | disclosed |
| CN-110724677-B | Agarase and preparation method thereof | 中国海洋大学 | 2022-08-05 | — | — | CN | disclosed |
| US-20220054634-A1 | Anti-IL-23 Antibodies, Compositions, Methods and Uses | JANSSEN BIOTECH INC (US) | 2022-02-24 | — | — | US | disclosed |
| US-20220048985-A1 | Anti-IL-6 Antibody | JANSSEN BIOTECH INC (US) | 2022-02-17 | — | — | US | disclosed |
| WO-2005005604-A2 | ENGINEERED ANTI-TARGET IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES | CENTOCOR, INC. (US) | 2005-01-20 | — | — | WO | disclosed |
| US-20050008638-A1 | CNGH0005 polypeptides, antibodies, compositions, methods and uses | CENTOCOR, INC. | 2005-01-13 | — | — | US | disclosed |
| US-20040120956-A1 | CNGH0004 polypeptides, antibodies, compositions, methods and uses | CENTOCOR, INC. | 2004-06-24 | — | — | US | disclosed |
| WO-2004003147-A2 | CNGH0004 POLYPEPTIDES, ANTIBODIES, COMPOSITIONS, METHODS AND USES | CENTOCOR, INC. (US) | 2004-01-08 | — | — | WO | disclosed |
| WO-2004003149-A2 | CNGH0005 POLYPEPTIDES, ANTIBODIES, COMPOSITIONS, METHODS AND USES | CENTOCOR, INC. (US) | 2004-01-08 | — | — | WO | disclosed |
| WO-2004002424-A2 | MAMMALIAN EPO MIMETIC CH1 DELETED MIMETIBODIES, COMPOSITIONS, METHODS AND USES | CENTOCOR, INC. (US) | 2004-01-08 | — | — | WO | disclosed |
| WO-2004002417-A2 | MAMMALIAN CH1 DELETED MIMETIBODIES, COMPOSITIONS, METHODS AND USES | CENTOCOR, INC. (US) | 2004-01-08 | — | — | WO | disclosed |
| EP-1331928-A2 | PARTICLE FORMATION METHODS AND THEIR PRODUCTS | Nektar Therapeutics UK Limited (GB) | 2003-08-06 | — | — | EP | disclosed |
| US-20020114844-A1 | Particle formation methods and their products | NEKTAR THERAPEUTICS | 2002-08-22 | — | — | US | disclosed |
| WO-2002038127-A2 | PARTICLE FORMATION METHODS AND THEIR PRODUCTS | NEKTAR THERAPEUTICS UK LIMITED (GB) | 2002-05-16 | — | — | WO | disclosed |