Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112306 | 0.83 | DOT1L (0.41) | CCNCCDK8KMT2AHDAC8ALDH1A1 | |
| SCHEMBL16112586 | 0.83 | ALDH1A1 (0.46) | CCNCCDK8KMT2AALDH1A1HTT | |
| SCHEMBL3436463 | 0.73 | CCNC (0.42) | CCNCCDK8KMT2APIM1PIM2 | |
| SCHEMBL14800575 | 0.69 | NOTUM (0.47) | CCNCCDK8NR1H4KMT2APIM1 | |
| SCHEMBL132010 | 0.68 | PLA2G7 (0.43) | NR1H4ALDH1A1MCL1FFAR1 | |
| SCHEMBL16111746 | 0.68 | GAA (0.46) | CCNCCDK8KMT2AALDH1A1MAPK14 | |
| SCHEMBL5943863 | 0.67 | HDAC6 (0.61) | HDAC7HDAC8 | |
| Bicarbonate SCHEMBL1836484 | 0.67 | MCL1 (0.47) | KMT2AHDAC8ALDH1A1MCL1MEN1 | |
| SCHEMBL11161805 | 0.65 | MCL1 (0.57) | NR1H4MCL1AURKA | |
| SCHEMBL28113839 | 0.64 | HPGD (0.40) | KMT2ABACE1MCL1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014159214-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2014-10-02 | — | — | WO | disclosed |