Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | ALPL | P05186 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16112229 | 0.83 | CCNC (0.40) | CCNCCDK8HDAC8MAPK14MEN1 | |
| SCHEMBL16111746 | 0.82 | GAA (0.46) | CCNCCDK8MAPK14ALPLMEN1 | |
| SCHEMBL20792373 | 0.77 | MAPK14 (0.62) | MAPK14MEN1KMT2AALDH1A1 | |
| SCHEMBL20792417 | 0.72 | HSD11B1 (0.46) | CCNCCDK8MAPK14MEN1KMT2A | |
| SCHEMBL20792371 | 0.72 | HTT (0.56) | ALDH1A1 | |
| SCHEMBL1990297 | 0.69 | GABRP (0.52) | CCNCCDK8MAPK1ALPLMEN1 | |
| SCHEMBL16112307 | 0.69 | CCNC (0.41) | CCNCCDK8MAPK1NOTUMALPL | |
| SCHEMBL20792432 | 0.68 | MAPK14 (0.40) | CCNCCDK8MAPK14MAPK1MEN1 | |
| SCHEMBL5944029 | 0.67 | HDAC6 (0.61) | HDAC6HDAC8HDAC3HDAC1HDAC2 | |
| SCHEMBL16112586 | 0.66 | ALDH1A1 (0.46) | CCNCCDK8ALPLMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014159214-A1 | HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF | CHDI FOUNDATION, INC. (US) | 2014-10-02 | — | — | WO | disclosed |