Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.53 |
| ▸ | RORC | P51449 | 9/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29643208 | 0.88 | PTGER4 (0.63) | ALDH1A1HPGDPTGER4RORCKDM4E | |
| SCHEMBL5892136 | 0.88 | PTGER4 (0.63) | ALDH1A1HPGDPTGER4RORCKDM4E | |
| SCHEMBL17461813 | 0.85 | HPGD (0.56) | ALDH1A1HPGDPTGER4RORCCNR2 | |
| SCHEMBL16099363 | 0.84 | PTGER4 (0.46) | PTGER4RORCCNR2PSEN1PSEN2 | |
| SCHEMBL11752123 | 0.83 | DRD2 (0.50) | PTGER4RORCCNR2PSEN1PSEN2 | |
| SCHEMBL9103614 | 0.82 | GPR3 (0.57) | ALDH1A1HPGDPTGER4RORCKDM4E | |
| SCHEMBL16093624 | 0.81 | HRH1 (0.45) | ALDH1A1HPGDPTGER4RORCMAPT | |
| SCHEMBL153959 | 0.80 | ALDH1A1 (0.62) | ALDH1A1HPGDRORCCNR2KDM4E | |
| SCHEMBL30012682 | 0.80 | ALDH1A1 (0.62) | ALDH1A1HPGDRORCCNR2KDM4E | |
| SCHEMBL30854944 | 0.80 | ALDH1A1 (0.62) | ALDH1A1HPGDRORCCNR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160024083-A1 | COMPOUNDS AND METHODS FOR TREATING CANCERS | HEALTH RESEARCH, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| US-20160024083-A1 | COMPOUNDS AND METHODS FOR TREATING CANCERS | HEALTH RESEARCH, INC. (US) | 2016-01-28 | — | — | US | disclosed |
| WO-2014153043-A1 | COMPOUNDS AND METHODS FOR TREATING CANCERS | HEALTH RESEARCH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024083-A1 | COMPOUNDS AND METHODS FOR TREATING CANCERS | AR, KLK3, BRDT | ALDH1A1 371/4885HPGD 166/4885PTGER4 838/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.