Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 1/20 | 0.56 |
| ▸ | CASP7 | P55210 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | RORA | P35398 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.47 |
| ▸ | RORB | Q92753 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29038434 | 0.90 | RORA (0.60) | MAPTPOLBLMNAUSP2TSHR | |
| SCHEMBL29038442 | 0.88 | PGR (0.54) | MAPTLMNAPGRRORARORC | |
| SCHEMBL17461858 | 0.88 | PDE4A (0.51) | MAPTPOLBLMNAUSP2TSHR | |
| SCHEMBL19009217 | 0.86 | PTGER4 (0.57) | MAPTLMNAUSP2TSHRMAPK1 | |
| SCHEMBL17461857 | 0.84 | MAOA (0.50) | MAPTPOLBLMNAUSP2TSHR | |
| SCHEMBL24822481 | 0.83 | HTR6 (0.51) | MAPTPOLBLMNAUSP2TSHR | |
| SCHEMBL24822434 | 0.83 | HDAC3 (0.47) | MAPTPOLBTSHRHDAC3HDAC1 | |
| SCHEMBL12110553 | 0.80 | MAPT (0.56) | MAPTPOLBLMNAUSP2TSHR | |
| SCHEMBL17274752 | 0.80 | MAPT (0.64) | MAPTPOLBLMNAUSP2TSHR | |
| SCHEMBL153959 | 0.80 | ALDH1A1 (0.62) | MAPTPOLBLMNAUSP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116217567-B | Hydrocarbyl-substituted alpha-carboline analogue or pharmaceutically acceptable salt thereof, pharmaceutical composition thereof, preparation method and application thereof | 潍坊医学院 | 2024-06-14 | — | — | CN | disclosed |
| CN-116217567-A | Hydrocarbyl-substituted alpha-carboline analogue or pharmaceutically acceptable salt thereof, pharmaceutical composition thereof, preparation method and application thereof | 潍坊医学院 | 2023-06-06 | — | — | CN | disclosed |
| WO-2014153043-A1 | COMPOUNDS AND METHODS FOR TREATING CANCERS | HEALTH RESEARCH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |