SCHEMBL16127262

SCHEMBL16127262

Fc1cncc(F)c1-c1cccc(C(F)(F)F)c1-n1c2ccccc2c2ccccc21

nearest known ligand 0.39

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.38
CYP11B2 P19099 2/20 0.38
HSD11B1 P28845 6/20 0.36
TRPA1 O75762 3/20 0.36
DUSP3 P51452 1/20 0.35
RORC P51449 1/20 0.33
AXL P30530 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP19A1 P11511 1/20 0.33
CYP2C9 P11712 1/20 0.33
ALOX5AP P20292 1/20 0.33
FEN1 P39748 1/20 0.33
SCN9A Q15858 1/20 0.33
ENPP1 P22413 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16127425 0.89 HSD11B1 (0.39) HSD11B1TRPA1RORC
SCHEMBL16127312 0.84 CYP11B1 (0.31) CYP11B1CYP11B2RORC
SCHEMBL16127239 0.83 HSD11B1 (0.36) HSD11B1TRPA1DUSP3RORC
SCHEMBL17563128 0.81 ALKBH5 (0.36) CYP11B1CYP11B2DUSP3
SCHEMBL17563166 0.78 KDM4E (0.43) HSD11B1DUSP3RORCAXL
SCHEMBL16127269 0.77 MAPK14 (0.40) HSD11B1RORCCYP2D6CYP2C9SCN9A
SCHEMBL16127311 0.76 NR3C1 (0.34) HSD11B1TRPA1RORC
SCHEMBL16127430 0.75 KDM4E (0.41) DUSP3
SCHEMBL16127313 0.73 KCNN4 (0.34) CYP11B1CYP11B2HSD11B1TRPA1CYP3A4
SCHEMBL16127323 0.73 PDK2 (0.32) HSD11B1RORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3375785-B1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2020-08-05 EP disclosed
US-10193079-B2 Materials for electronic devices MERCK PATENT GMBH (DE) 2019-01-29 US disclosed
EP-2976329-B1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2018-06-27 EP disclosed
US-20160072076-A1 MATERIALS FOR ELECTRONIC DEVICES UDC IRELAND LIMITED (IE) 2016-03-10 US disclosed
WO-2014146752-A1 MATERIALS FOR ELECTRONIC DEVICES MERCK PATENT GMBH (DE) 2014-09-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160072076-A1 MATERIALS FOR ELECTRONIC DEVICES AOC3, AOC2, AOC1 CYP11B1 619/4885CYP11B2 395/4885HSD11B1 2650/4885
US-10193079-B2 Materials for electronic devices AOC3, AOC2, AOC1 CYP11B1 619/4885CYP11B2 395/4885HSD11B1 2650/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.