Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | YTHDC1 | Q96MU7 | 3/20 | 0.47 |
| ▸ | CDK1 | P06493 | 6/20 | 0.46 |
| ▸ | KCNN3 | Q9UGI6 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828319 | 0.85 | YTHDC1 (0.66) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL13708308 | 0.81 | CDK1 (0.49) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL130527 | 0.81 | CDK1 (0.64) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL20998612 | 0.80 | YTHDC1 (0.73) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL12702671 | 0.80 | PI4KA (0.43) | PDE4APDE4BPDE4CPDE4DYTHDC1 | |
| SCHEMBL12724436 | 0.80 | CDK1 (0.53) | YTHDC1CDK1ADORA2AADORA1CCNB1 | |
| SCHEMBL17442999 | 0.74 | CDK1 (0.73) | CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL16513142 | 0.74 | CTSL (0.53) | PDE4APDE4BPDE4CPDE4DCDK1 | |
| SCHEMBL17450185 | 0.74 | CDK1 (0.58) | CDK1CCNB1CCNE1CDK2 | |
| SCHEMBL23027205 | 0.74 | CDK1 (0.42) | PDE4APDE4BPDE4CPDE4DYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2265626-B1 | NUCLEOTIDE ANALOGUES WITH QUATERNARY CARBON STEREOGENIC CENTERS AND METHODS OF USE | LCB PHARMA INC (CA) | 2019-05-15 | — | — | EP | disclosed |
| US-8846636-B2 | Nucleoside analogues with quaternary carbon stereogenic centers and methods of use | LCB PHARMA INC. (CA) | 2014-09-30 | — | — | US | disclosed |