Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | SOD3 | P08294 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1662690 | 0.98 | MEN1 (0.42) | MEN1KMT2AGBA1SOD3ALOX5 | |
| Bromide SCHEMBL28435713 | 0.98 | MEN1 (0.42) | MEN1KMT2AGBA1SOD3ALOX5 | |
| SCHEMBL1583492 | 0.98 | GBA1 (0.43) | MEN1KMT2AGBA1SOD3ALOX5 | |
| SCHEMBL6566169 | 0.98 | GBA1 (0.43) | MEN1KMT2AGBA1SOD3ALOX5 | |
| Hydrochloric Acid SCHEMBL7528001 | 0.97 | SOD3 (0.44) | MEN1KMT2AGBA1SOD3ALOX5 | |
| Hydrochloric Acid SCHEMBL6479261 | 0.97 | SOD3 (0.44) | MEN1KMT2AGBA1SOD3ALOX5 | |
| SCHEMBL1583265 | 0.95 | MEN1 (0.49) | MEN1KMT2AGBA1SOD3ALOX5 | |
| Hypochlorous Acid SCHEMBL6479265 | 0.94 | GBA1 (0.43) | MEN1KMT2AGBA1SOD3ALOX5 | |
| Bromide SCHEMBL28431073 | 0.93 | MEN1 (0.47) | MEN1KMT2AGBA1SOD3ALOX5 | |
| SCHEMBL1583740 | 0.87 | MEN1 (0.35) | MEN1KMT2ASOD3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424869-B1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LTD (GB) | 2016-06-22 | — | — | EP | disclosed |
| CN-104277040-A | Acyl piperazinone substituent-containing pyrazolopiperidone compound and composition and use thereof | GUANGDONG HEC PHARMACEUTICAL | 2015-01-14 | — | — | CN | disclosed |
| CN-104277040-A | Acyl piperazinone substituent-containing pyrazolopiperidone compound and composition and use thereof | GUANGDONG HEC PHARMACEUTICAL | 2015-01-14 | — | — | CN | disclosed |
| US-8501946-B2 | 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine derivatives as P2X7 modulators | GLAXO GROUP LIMITED (GB) | 2013-08-06 | — | — | US | disclosed |
| EP-2254884-B1 | 3-ALKYL-PIPERAZINE DERIVATIVES AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2013-05-01 | — | — | EP | disclosed |
| US-20120157436-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2012-06-21 | — | — | US | disclosed |
| EP-2424869-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2012-03-07 | — | — | EP | disclosed |
| US-7998963-B2 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC (US) | 2011-08-16 | — | — | US | disclosed |
| WO-2011050284-A1 | PYRAZOLYLPYRIDINE ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-28 | — | — | WO | disclosed |
| EP-2254884-A2 | 3-ALKYL-PIPERAZINE DERIVATIVES AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2010-12-01 | — | — | EP | disclosed |
| US-20090209553-A1 | Arylpiperazine derivatives and uses thereof | ROCHE PALO ALTO LLC | 2009-08-20 | — | — | US | disclosed |
| WO-2009101018-A2 | 3-ALKYL-PIPERAZINE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-20 | — | — | WO | disclosed |
| US-6458935-B1 | LABEL FPTASE IN ASSAYS, WHETHER CELL-BASED, TISSUE-BASED OR IN WHOLE ANIMAL. THE TRACERS CAN ALSO BE USED IN COMPETITIVE BINDING ASSAYS TO OBTAIN INFORMATION ON THE INTERACTION OF UNLABELED FTIS WITH FPTASE. | MERCK & CO., INC. | 2002-10-01 | — | — | US | disclosed |
| WO-2000078363-A1 | RADIOLABELED FARNESYL-PROTEIN TRANSFERASE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |
| US-6160118-A | Process for the synthesis of substituted piperazinones via Mitsunobu reaction | MERCK & CO., INC. (US) | 2000-12-12 | — | — | US | disclosed |
| WO-2000001678-A1 | PROCESS FOR THE SYNTHESIS OF SUBSTITUTED PIPERAZINONES VIA MITSUNOBU REACTION | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |
| US-4880934-A | Preparation of hydroxyalkylpiperazinones by reacting a 2,3-dihydroxy-1,4-dioxane with a hydroalkyldiamine | THE DOW CHEMICAL COMPANY (US) | 1989-11-14 | — | — | US | disclosed |
| US-4814447-A | Preparation of hydroxyalkylpiperazinones by reacting an alkylene oxide with decahydropyrazino[2,3-b]pyrazine or its substituted derivatives | THE DOW CHEMICAL COMPANY (US) | 1989-03-21 | — | — | US | disclosed |
| US-4814443-A | Preparation of hydroxyalkylpiperazinones by reacting glyoxal with hydroxyalkyldiamines | THE DOW CHEMICAL COMPANY (US) | 1989-03-21 | — | — | US | disclosed |
| EP-0011693-A1 | N-trifluoromethane-sulfonylaminophenyl-substituted N-heterocycles, their preparation, compositions containing them and their use in regulating plant growth | CIBA-GEIGY AG (CH) | 1980-06-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209553-A1 | Arylpiperazine derivatives and uses thereof | ADRA2C, AHR, CYP1A2 | MEN1 3850/4885KMT2A 1747/4885GBA1 1782/4885 |
| US-20120157436-A1 | 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-a]PYRAZINE DERIVATIVES AS P2X7 MODULATORS | P2RX7, P2RX6, P2RX3 | MEN1 4170/4885KMT2A 4184/4885GBA1 2342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.