Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | ARF6 | P62330 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13516328 | 1.00 | TP53 (0.48) | TP53NPC1NPSR1KMT2AMEN1 | |
| SCHEMBL13515966 | 0.95 | MAPT (0.46) | TP53NPC1NPSR1KMT2AMEN1 | |
| SCHEMBL1614504 | 0.92 | ADORA2A (0.45) | TP53NPC1NPSR1KMT2AMEN1 | |
| SCHEMBL13516556 | 0.90 | ADORA2A (0.41) | TP53NPC1KMT2AMEN1RAB9A | |
| SCHEMBL1614418 | 0.89 | PSD (0.45) | TP53NPC1KMT2AMEN1RAB9A | |
| SCHEMBL19084549 | 0.89 | PSD (0.45) | TP53NPC1KMT2AMEN1RAB9A | |
| SCHEMBL24221653 | 0.88 | PLAT (0.43) | TP53NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL13516682 | 0.88 | CDC7 (0.46) | NPC1NPSR1KMT2AMEN1RAB9A | |
| SCHEMBL13516471 | 0.88 | PLAT (0.43) | TP53NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL13516124 | 0.87 | GCGR (0.44) | NPC1KMT2AMEN1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170216332-A1 | SMALL MOLECULE ANTI-SCARRING AGENTS | UNIVERSITY OF ROCHESTER (US) | 2017-08-03 | — | — | US | claimed |
| WO-2015195684-A2 | SMALL MOLECULE ANTI-SCARRING AGENTS | UNIVERSITY OF ROCHESTER (US) | 2015-12-23 | — | — | WO | claimed |
| US-20220023270-A1 | ANTIBACTERIAL COMPOUNDS AND USES THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2022-01-27 | — | — | US | disclosed |
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | BIOENERGENIX LLC (US) | 2021-03-23 | — | — | US | disclosed |
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | BIOENERGENIX LLC (US) | 2021-03-23 | — | — | US | disclosed |
| US-10548911-B2 | Small molecule anti-scarring agents | UNIVERSITY OF ROCHESTER (US) | 2020-02-04 | — | — | US | disclosed |
| US-10548911-B2 | Small molecule anti-scarring agents | UNIVERSITY OF ROCHESTER (US) | 2020-02-04 | — | — | US | disclosed |
| US-20170216332-A1 | SMALL MOLECULE ANTI-SCARRING AGENTS | UNIVERSITY OF ROCHESTER (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170216332-A1 | SMALL MOLECULE ANTI-SCARRING AGENTS | UNIVERSITY OF ROCHESTER (US) | 2017-08-03 | — | — | US | disclosed |
| WO-2015195684-A2 | SMALL MOLECULE ANTI-SCARRING AGENTS | UNIVERSITY OF ROCHESTER (US) | 2015-12-23 | — | — | WO | disclosed |
| WO-2015195684-A2 | SMALL MOLECULE ANTI-SCARRING AGENTS | UNIVERSITY OF ROCHESTER (US) | 2015-12-23 | — | — | WO | disclosed |
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |
| WO-2012149157-A2 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2012-11-01 | — | — | WO | disclosed |
| US-20120277224-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120277224-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2012-11-01 | — | — | US | disclosed |
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | PEKING UNIVERSITY (CN) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277224-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | PASK, PDXK, PANK2 | TP53 1469/4885NPC1 3570/4885NPSR1 971/4885 |
| US-20170216332-A1 | SMALL MOLECULE ANTI-SCARRING AGENTS | COLGALT1, MMP1, FIBP | TP53 2310/4885NPC1 4426/4885NPSR1 4044/4885 |
| US-20220023270-A1 | ANTIBACTERIAL COMPOUNDS AND USES THEREOF | CLPP, SPOUT1, MRPL21 | TP53 3376/4885NPC1 1188/4885NPSR1 3921/4885 |
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | KCNJ2, KCNQ5, KCNJ11 | TP53 4179/4885NPC1 1230/4885NPSR1 530/4885 |
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | PASK, PDXK, PANK2 | TP53 1469/4885NPC1 3570/4885NPSR1 971/4885 |
| US-10548911-B2 | Small molecule anti-scarring agents | COLGALT1, MMP1, FIBP | TP53 2310/4885NPC1 4426/4885NPSR1 4044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.