Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | NR1H2 | P55055 | 9/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20685539 | 0.78 | CHRM2 (0.57) | GPR119OPRM1OPRD1OGFRL1KDM4E | |
| SCHEMBL16827989 | 0.78 | GPR119 (0.55) | GPR119KDM4EPKMUSP30MMP13 | |
| SCHEMBL30344944 | 0.76 | KMT2A (0.53) | OPRM1OPRD1KDM4EKMT2A | |
| SCHEMBL3097660 | 0.76 | BRD4 (0.48) | GPR119OPRM1OPRD1OGFRL1USP30 | |
| SCHEMBL14367891 | 0.76 | NR1H2 (0.75) | NR1H2NR1H3 | |
| SCHEMBL3159082 | 0.75 | GPR119 (0.52) | GPR119OPRM1OPRD1OGFRL1KDM4E | |
| SCHEMBL947135 | 0.75 | LMNA (0.62) | GPR119OPRM1OPRD1OGFRL1KDM4E | |
| SCHEMBL16827952 | 0.75 | GPR119 (0.52) | GPR119KDM4EPKMUSP30MEN1 | |
| SCHEMBL3957088 | 0.75 | DRD4 (0.58) | GPR119 | |
| SCHEMBL6160925 | 0.74 | HSD11B1 (0.56) | GPR119OPRM1OPRD1OGFRL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014160478-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB (US) | 2014-10-02 | — | — | WO | disclosed |