Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 4/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 4/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 4/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD5 | P21918 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2301 | 0.85 | SCN1A (0.47) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL2126 | 0.83 | SCN1A (0.48) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL3201 | 0.81 | SCN1A (0.49) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL707956 | 0.79 | SLC6A3 (0.67) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL1615 | 0.75 | SCN1A (0.51) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL9569998 | 0.75 | SLC6A3 (0.47) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL3019 | 0.72 | ADRB3 (0.42) | SCN1ASCN2ASCN3ABDKRB1 | |
| SCHEMBL9597954 | 0.72 | KDM4E (0.50) | DRD1DRD2DRD4DRD5DRD3 | |
| SCHEMBL29951779 | 0.72 | KDM4E (0.50) | DRD1DRD2DRD4DRD5DRD3 | |
| SCHEMBL27636054 | 0.70 | SCN1A (0.62) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |