Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 2/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2126 | 0.86 | SCN1A (0.48) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL1614 | 0.85 | SCN1A (0.47) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL3201 | 0.84 | SCN1A (0.49) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL31316347 | 0.78 | SLC6A3 (0.56) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL249 | 0.77 | SLC6A3 (0.73) | SLC6A3SLC6A4SLC6A2SMN1; SMN2MAPT | |
| SCHEMBL28731480 | 0.75 | ALDH1A1 (0.66) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL3019 | 0.75 | ADRB3 (0.42) | SCN1ASCN2ASCN3AMAPK1 | |
| SCHEMBL3230316 | 0.74 | TSHR (0.65) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL29500171 | 0.74 | TSHR (0.65) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 | |
| SCHEMBL27636054 | 0.73 | SCN1A (0.62) | SCN1ASCN2ASCN3ASLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |