SCHEMBL16144184

SCHEMBL16144184

CC(C)(O)OCCC(=O)O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HMGCR P04035 1/20 0.40
CHRM1 P11229 1/20 0.40
TBXA2R P21731 1/20 0.40
ADRA1A P35348 1/20 0.40
LMNA P02545 5/20 0.38
EGLN1 Q9GZT9 2/20 0.38
ALKBH5 Q6P6C2 1/20 0.38
SUCNR1 Q9BXA5 1/20 0.38
ALDH1A1 P00352 2/20 0.38
FFAR3 O14843 1/20 0.38
HDAC3 O15379 1/20 0.38
HDAC1 Q13547 1/20 0.38
HDAC2 Q92769 1/20 0.38
HDAC8 Q9BY41 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.36
SLC15A2 Q16348 1/20 0.36
TSHR P16473 4/20 0.35
SLC22A6 Q4U2R8 1/20 0.35
NAALAD2 Q9Y3Q0 1/20 0.34
CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL242553 0.82 LMNA (0.40) HMGCRCHRM1TBXA2RADRA1ALMNA
SCHEMBL19821761 0.79 HMGCR (0.36) HMGCRCHRM1TBXA2RADRA1ALMNA
SCHEMBL18191548 0.78 NAALAD2 (0.38) HMGCRCHRM1TBXA2RADRA1ALMNA
SCHEMBL21510518 0.78 ALDH1A1 (0.37) HMGCRCHRM1TBXA2RADRA1ALMNA
SCHEMBL19822060 0.76 FFAR3 (0.40) LMNAEGLN1ALKBH5SUCNR1ALDH1A1
SCHEMBL19336827 0.73 CTSD (0.46) LMNAALDH1A1L3MBTL1CYP2D6CYP2C19
SCHEMBL19203186 0.73 ALDH1A1 (0.33) HMGCRCHRM1TBXA2RADRA1ALMNA
SCHEMBL4613655 0.72 LMNA (0.40) LMNAEGLN1ALKBH5SUCNR1ALDH1A1
SCHEMBL46780 0.72 DGAT1 (0.38) LMNAEGLN1ALKBH5SUCNR1ALDH1A1
SCHEMBL21896383 0.71 HMGCR (0.37) HMGCRCHRM1TBXA2RADRA1ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3168216-A1 AZETIDINYLOXYPHENYLPYRROLIDINE COMPOUNDS Eli Lilly and Company (US) 2017-05-17 EP disclosed
EP-2970222-B1 AZETIDINYLOXYPHENYLPYRROLIDINE COMPOUNDS LILLY CO ELI (US) 2016-12-21 EP disclosed
WO-2016033776-A1 CRYSTALLINE (2S) -3- [ (3S, 4S) -3- [ (1R) -1-HYDROXYETHYL] -4- (4-METHOXY-3- { [1- (5-METHYLPYRIDIN-2-YL) AZETIDIN-3-YL] OXY} PHENYL) -3-METHYLPYRROLIDIN-1-YL] -3-OXOPROPANE-1, 2-DIOL ELI LILLY AND COMPANY (US) 2016-03-10 WO disclosed
WO-2016036596-A1 CRYSTALLINE (2S)-3-[(3S,4S)-3-[(1R)-1-HYDROXYETHYL]-4-(4-METHOXY-3-{[1-(5-METHYLPYRIDIN-2-YL)AZETIDIN-3-YL]OXY}PHENYL) -3-METHYLPYRROLIDIN-1-YL]-3-OXOPROPANE-1,2-DIOL ELI LILLY AND COMPANY (US) 2016-03-10 WO disclosed
WO-2014159012-A9 AZETIDINYLOXYPHENYLPYRROLIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2014-12-18 WO disclosed
WO-2014159012-A1 AZETIDINYLOXYPHENYLPYRROLIDINE COMPOUNDS ELI LILLY AND COMPANY (US) 2014-10-02 WO disclosed