Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 2/20 | 0.48 |
| ▸ | GABRD | O14764 | 2/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.48 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.48 |
| ▸ | GABRE | P78334 | 2/20 | 0.48 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.48 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.48 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.48 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.48 |
| ▸ | HCAR2 | Q8TDS4 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956892 | 1.00 | GABRP (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3733228 | 1.00 | GABRP (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3733226 | 1.00 | GABRP (0.48) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL15691960 | 0.84 | TSHR (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL29860909 | 0.83 | TSHR (0.55) | HCAR2TSHRALDH1A1CHRM2CHRM4 | |
| SCHEMBL2357069 | 0.80 | GABRP (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL2357063 | 0.80 | GABRP (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3131666 | 0.80 | GABRP (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL3131678 | 0.80 | GABRP (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL18392565 | 0.80 | TSHR (0.42) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230159552-A1 | MEAYAMYCIN AND ITS ANALOGUES, METHODS FOR THEIR PREPARATION, AND METHODS OF USE | THE SCRIPPS RESEARCH INSTITUTE | 2023-05-25 | — | — | US | disclosed |
| US-11584754-B2 | Derivatives of thailanstatin A, methods of treatment and methods of synthesis thereof | WILLIAM MARSH RICE UNIVERSITY (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210395265-A1 | ANTI-CANCER AGENTS AND PREPARATION THEREOF | PURDUE RESEARCH FOUNDATION | 2021-12-23 | — | — | US | disclosed |
| US-10858371-B2 | Anti-cancer agents and preparation thereof | PURDUE RESEARCH FOUNDATION (US) | 2020-12-08 | — | — | US | disclosed |
| US-20190218228-A1 | ANTI-CANCER AGENTS AND PREPARATION THEREOF | PURDUE RESEARCH FOUNDATION | 2019-07-18 | — | — | US | disclosed |
| US-10000505-B2 | Anti-cancer agents and preparation thereof | PURDUE RESEARCH FOUNDATION (US) | 2018-06-19 | — | — | US | disclosed |
| US-10000505-B2 | Anti-cancer agents and preparation thereof | PURDUE RESEARCH FOUNDATION (US) | 2018-06-19 | — | — | US | disclosed |
| US-20160297831-A1 | ANTI-CANCER AGENTS AND PREPARATION THEREOF | PURDUE RESEARCH FOUNDATION | 2016-10-13 | — | — | US | disclosed |
| US-20160297831-A1 | ANTI-CANCER AGENTS AND PREPARATION THEREOF | PURDUE RESEARCH FOUNDATION | 2016-10-13 | — | — | US | disclosed |
| US-8309599-B2 | Synthesis of FR901464 and analogs with antitumor activity | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-11-13 | — | — | US | disclosed |
| US-20110086909-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | UNIVERSITY OF PITTSBURGH-- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-04-14 | — | — | US | disclosed |
| US-20110086909-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | UNIVERSITY OF PITTSBURGH-- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-04-14 | — | — | US | disclosed |
| US-20110086909-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | UNIVERSITY OF PITTSBURGH-- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2011-04-14 | — | — | US | disclosed |
| US-7825267-B2 | Synthesis of FR901464 and analogs with antitumor activity | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-11-02 | — | — | US | disclosed |
| US-7825267-B2 | Synthesis of FR901464 and analogs with antitumor activity | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-11-02 | — | — | US | disclosed |
| US-7825267-B2 | Synthesis of FR901464 and analogs with antitumor activity | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2010-11-02 | — | — | US | disclosed |
| WO-2009031999-A1 | FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY AND METHOD FOR THEIR PREPARATION | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2009-03-12 | — | — | WO | disclosed |
| US-20080096879-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | UNIVERSITY OF PITTSBURGH-- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-04-24 | — | — | US | disclosed |
| US-20080096879-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | UNIVERSITY OF PITTSBURGH-- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-04-24 | — | — | US | disclosed |
| US-20080096879-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | UNIVERSITY OF PITTSBURGH-- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096879-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | RBM17, SF3B1, RTCB | GABRP 4239/4885GABRD 4081/4885GABRA1 3852/4885 |
| US-20160297831-A1 | ANTI-CANCER AGENTS AND PREPARATION THEREOF | SF1, ELOB, SF3B1 | GABRP 3791/4885GABRD 3979/4885GABRA1 3472/4885 |
| US-20210395265-A1 | ANTI-CANCER AGENTS AND PREPARATION THEREOF | TP53, VHL, MCL1 | GABRP 4631/4885GABRD 4799/4885GABRA1 4439/4885 |
| US-10000505-B2 | Anti-cancer agents and preparation thereof | SF1, ELOB, SF3B1 | GABRP 3791/4885GABRD 3979/4885GABRA1 3472/4885 |
| US-20230159552-A1 | MEAYAMYCIN AND ITS ANALOGUES, METHODS FOR THEIR PREPARATION, AND METHODS OF USE | MRM1, MGAM, MEP1A | GABRP 3676/4885GABRD 4518/4885GABRA1 4095/4885 |
| US-11584754-B2 | Derivatives of thailanstatin A, methods of treatment and methods of synthesis thereof | NAMPT, FNTA, GNPAT | GABRP 3942/4885GABRD 3668/4885GABRA1 3727/4885 |
| US-20110086909-A1 | SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY | RBM17, SF3B1, RTCB | GABRP 4239/4885GABRD 4081/4885GABRA1 3852/4885 |
| US-10858371-B2 | Anti-cancer agents and preparation thereof | TP53, VHL, MCL1 | GABRP 4631/4885GABRD 4799/4885GABRA1 4439/4885 |
| US-20190218228-A1 | ANTI-CANCER AGENTS AND PREPARATION THEREOF | TP53, VHL, MCL1 | GABRP 4631/4885GABRD 4799/4885GABRA1 4439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.