Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777934 | 0.80 | TSHR (0.38) | TSHRTDP1ALDH1A1HSD17B10ADRB2 | |
| SCHEMBL27433629 | 0.78 | TSHR (0.44) | TSHRTDP1MEN1KMT2AMAPK1 | |
| SCHEMBL8447329 | 0.75 | CHRNB2 (0.41) | TDP1ALDH1A1ADRB2ADRB1ADRB3 | |
| SCHEMBL3671321 | 0.73 | LMNA (0.46) | TSHRTDP1ALDH1A1HSD17B10MEN1 | |
| SCHEMBL27441320 | 0.73 | SMN1; SMN2 (0.43) | TSHRALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL6265499 | 0.72 | ADRB2 (0.40) | TDP1ALDH1A1ADRB2ADRB1ADRB3 | |
| SCHEMBL6265500 | 0.72 | ADRB2 (0.40) | TDP1ALDH1A1ADRB2ADRB1ADRB3 | |
| SCHEMBL9618428 | 0.72 | LMNA (0.45) | TSHRTDP1ALDH1A1MEN1KMT2A | |
| SCHEMBL28498515 | 0.72 | MAPK1 (0.50) | TSHRTDP1ALDH1A1HSD17B10ADRB2 | |
| SCHEMBL8745381 | 0.72 | NPC1 (0.40) | ALDH1A1MEN1KMT2AMAPK1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014165075-A1 | ANTIBACTERIAL AGENTS | ACHAOGEN, INC. (US) | 2014-10-09 | — | — | WO | disclosed |