SCHEMBL8745381

SCHEMBL8745381

CO[C@]1(CO[Si](C)(C)C(C)(C)C)CC[C@@H](COC(=O)c2ccccc2)O1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.40
KMT2A Q03164 2/20 0.39
MEN1 O00255 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
CHRNB2 P17787 1/20 0.38
CHRNA5 P30532 1/20 0.38
CHRNA7 P36544 1/20 0.38
CHRNA4 P43681 1/20 0.38
ALDH1A1 P00352 3/20 0.38
POLB P06746 2/20 0.37
GAA P10253 2/20 0.37
MAPK1 P28482 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
LMNA P02545 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
MAPT P10636 2/20 0.36
CYP3A4 P08684 1/20 0.36
CES2 O00748 1/20 0.35
CARM1 Q86X55 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8745444 0.88 NPC1 (0.46) NPC1KMT2AMEN1CYP1A2CYP2C19
SCHEMBL8745391 0.88 NPC1 (0.46) NPC1KMT2AMEN1CYP1A2CYP2C19
SCHEMBL8745393 0.88 NPC1 (0.46) NPC1KMT2AMEN1CYP1A2CYP2C19
SCHEMBL8745371 0.78 NPC1 (0.42) NPC1KMT2AMEN1CYP1A2CYP2C19
SCHEMBL8447329 0.77 CHRNB2 (0.41) NPC1CHRNB2CHRNA5CHRNA7CHRNA4
SCHEMBL16148176 0.72 TSHR (0.38) KMT2AMEN1CYP1A2CYP2C19CHRNB2
SCHEMBL23797087 0.71 ALDH1A1 (0.48) NPC1KMT2AMEN1CHRNB2CHRNA5
SCHEMBL20729515 0.71 ALDH1A1 (0.48) NPC1KMT2AMEN1CHRNB2CHRNA5
SCHEMBL8745366 0.70 MAPT (0.50) KMT2AMEN1CHRNB2CHRNA5CHRNA7
SCHEMBL28498515 0.70 MAPK1 (0.50) NPC1KMT2AALDH1A1GAAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0707590-A1 DIDEOXYFRUCTONUCLEOTIDES AND DEOXYFRUCTONUCLEOTIDES AS DNA POLYMERASE SUBSTRATES DU PONT (US) 1996-04-24 EP disclosed
WO-1995001986-A1 DIDEOXYFRUCTONUCLEOTIDES AND DEOXYFRUCTONUCLEOTIDES AS DNA POLYMERASE SUBSTRATES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1995-01-19 WO disclosed
US-5276143-A Dideoxyfructonucleosides and deoxyfructonucleotides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1994-01-04 US disclosed