Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 12/20 | 0.65 |
| ▸ | CDK8 | P49336 | 12/20 | 0.65 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.60 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.60 |
| ▸ | CCNK | O75909 | 1/20 | 0.54 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17714082 | 0.85 | SIGMAR1 (0.53) | CCNCCDK8MKNK1MKNK2SIGMAR1 | |
| SCHEMBL8260488 | 0.83 | SIGMAR1 (0.72) | CCNCCDK8MKNK1MKNK2SIGMAR1 | |
| SCHEMBL17437018 | 0.82 | CCNC (0.72) | CCNCCDK8 | |
| SCHEMBL17608512 | 0.79 | CCNC (0.75) | CCNCCDK8 | |
| SCHEMBL16574186 | 0.79 | GABRD (0.66) | CCNCCDK8MKNK1MKNK2SIGMAR1 | |
| SCHEMBL17389728 | 0.79 | FASN (0.66) | CCNKCDK12 | |
| SCHEMBL8358137 | 0.78 | SIGMAR1 (0.81) | MKNK1MKNK2SIGMAR1HPGDL3MBTL1 | |
| SCHEMBL7425708 | 0.78 | MKNK1 (0.72) | CCNCCDK8MKNK1MKNK2SIGMAR1 | |
| SCHEMBL5266293 | 0.77 | SIGMAR1 (0.80) | CCNCCDK8MKNK1MKNK2SIGMAR1 | |
| SCHEMBL8934929 | 0.77 | SIGMAR1 (0.64) | CCNCCDK8MKNK1MKNK2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2968316-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | Forma Therapeutics, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014164749-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN | FORMA THERAPEUTICS, INC. (US) | 2014-10-09 | — | — | WO | disclosed |