Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.64 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | CCNC | P24863 | 7/20 | 0.57 |
| ▸ | CDK8 | P49336 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4505138 | 0.95 | SIGMAR1 (0.70) | SIGMAR1MKNK1MKNK2HPGDCCNC | |
| SCHEMBL8260488 | 0.93 | SIGMAR1 (0.72) | SIGMAR1MKNK1MKNK2HPGDCCNC | |
| SCHEMBL8358137 | 0.87 | SIGMAR1 (0.81) | SIGMAR1MKNK1MKNK2HPGDL3MBTL1 | |
| SCHEMBL5266293 | 0.86 | SIGMAR1 (0.80) | SIGMAR1MKNK1MKNK2HPGDCCNC | |
| SCHEMBL16574186 | 0.85 | GABRD (0.66) | SIGMAR1MKNK1MKNK2HPGDCCNC | |
| Hydrochloric Acid SCHEMBL4763940 | 0.85 | SIGMAR1 (0.77) | SIGMAR1MKNK1MKNK2HPGDCCNC | |
| SCHEMBL29800584 | 0.85 | SIGMAR1 (0.62) | SIGMAR1MKNK1MKNK2HPGDCCNC | |
| SCHEMBL7425708 | 0.83 | MKNK1 (0.72) | SIGMAR1MKNK1MKNK2HPGDCCNC | |
| SCHEMBL3583338 | 0.82 | HPGD (0.73) | SIGMAR1MKNK1MKNK2HPGDL3MBTL1 | |
| SCHEMBL14523155 | 0.81 | HPGD (0.64) | HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4276092-A1 | COMPOUND LIBRARY | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-11-15 | — | — | EP | disclosed |
| WO-2022149617-A1 | COMPOUND LIBRARY | 中外製薬株式会社 | 2022-07-14 | — | — | WO | disclosed |
| WO-1996029088-A1 | NOVEL PIPERAZINE DERIVATIVES AS TYPE IL-1 RECEPTOR ANTAGONISTS | AFFYMAX TECHNOLOGIES N.V. (AN) | 1996-09-26 | — | — | WO | disclosed |