Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.72 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.72 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.60 |
| ▸ | CCNC | P24863 | 7/20 | 0.57 |
| ▸ | CDK8 | P49336 | 7/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | LSS | P48449 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.54 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5273 | 0.92 | SIGMAR1 (0.70) | MKNK1MKNK2SIGMAR1HPGDRIPK1 | |
| Trifluoroacetic Acid SCHEMBL6199874 | 0.90 | L3MBTL1 (0.62) | MKNK1MKNK2SIGMAR1CCNCCDK8 | |
| Hydrochloric Acid SCHEMBL1597605 | 0.90 | SIGMAR1 (0.68) | MKNK1MKNK2SIGMAR1HPGDRIPK1 | |
| SCHEMBL8260488 | 0.90 | SIGMAR1 (0.72) | MKNK1MKNK2SIGMAR1CCNCCDK8 | |
| SCHEMBL8358137 | 0.84 | SIGMAR1 (0.81) | MKNK1MKNK2SIGMAR1L3MBTL1HPGD | |
| SCHEMBL8934929 | 0.83 | SIGMAR1 (0.64) | MKNK1MKNK2SIGMAR1CCNCCDK8 | |
| SCHEMBL5266293 | 0.83 | SIGMAR1 (0.80) | MKNK1MKNK2SIGMAR1CCNCCDK8 | |
| Hydrochloric Acid SCHEMBL4763940 | 0.82 | SIGMAR1 (0.77) | MKNK1MKNK2SIGMAR1CCNCCDK8 | |
| SCHEMBL16574186 | 0.82 | GABRD (0.66) | MKNK1MKNK2SIGMAR1CCNCCDK8 | |
| SCHEMBL29800584 | 0.82 | SIGMAR1 (0.62) | MKNK1MKNK2SIGMAR1CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1082321-A1 | HETEROCYCLIC DERIVATIVES WHICH INHIBIT FACTOR XA | AstraZeneca AB (SE) | 2001-03-14 | — | — | EP | disclosed |
| CN-1278793-A | Sulfonyl derivatives | DAIICHI SEIYAKU CO (JP) | 2001-01-03 | — | — | CN | disclosed |
| WO-1999057113-A1 | HETEROCYCLIC DERIVATIVES WHICH INHIBIT FACTOR XA | ASTRAZENECA AB (SE) | 1999-11-11 | — | — | WO | disclosed |