Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5744305 | 0.95 | LMNA (0.55) | LMNAKIF11MAPTKMT2APARP1 | |
| Ethane SCHEMBL3002447 | 0.83 | MAPT (0.59) | LMNAMAPTKMT2APARP1CYP3A4 | |
| SCHEMBL366365 | 0.83 | MAPT (0.58) | LMNAMAPTKMT2APARP1CYP3A4 | |
| SCHEMBL11627035 | 0.81 | LMNA (0.50) | LMNAKIF11MAPTKMT2APARP1 | |
| Hydrochloric Acid SCHEMBL23198120 | 0.81 | MAPT (0.56) | LMNAMAPTKMT2APARP1CYP3A4 | |
| SCHEMBL19770179 | 0.80 | LMNA (0.52) | LMNAKIF11KMT2ACYP2D6KCNH2 | |
| SCHEMBL6824958 | 0.79 | KIF11 (0.48) | LMNAKIF11MAPTKMT2APARP1 | |
| SCHEMBL4593887 | 0.78 | PARP1 (0.52) | LMNAKIF11MAPTKMT2APARP1 | |
| SCHEMBL27621135 | 0.77 | KMT2A (0.62) | LMNAKIF11MAPTKMT2APARP1 | |
| SCHEMBL30087612 | 0.75 | PARP1 (0.48) | LMNAKIF11MAPTKMT2APARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435423-B1 | SUBSTITUTED BENZOTRIAZINES AND QUINOXALINES AS INHIBITORS OF P70S6 KINASE | SENTINEL ONCOLOGY LTD (GB) | 2014-10-15 | — | — | EP | disclosed |