Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2967953 | 0.81 | ALDH1A1 (0.43) | ALDH1A1NPC1S1PR1S1PR3EDNRA | |
| SCHEMBL28815247 | 0.79 | ALDH1A1 (0.46) | ALDH1A1NPC1S1PR1S1PR3EDNRA | |
| SCHEMBL17696444 | 0.78 | NOS3 (0.52) | ALDH1A1UHRF1MAPTCYP1A2GRM5 | |
| SCHEMBL16268336 | 0.78 | KMT2A (0.52) | ALDH1A1NPC1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL19260116 | 0.76 | ALDH1A1 (0.40) | ALDH1A1NPC1S1PR1S1PR3EDNRA | |
| SCHEMBL17593229 | 0.76 | NPC1 (0.47) | ALDH1A1NPC1S1PR1S1PR3EDNRA | |
| SCHEMBL15254074 | 0.75 | KMT2A (0.39) | ALDH1A1NPC1KMT2AHTTMEN1 | |
| SCHEMBL15167171 | 0.75 | PLAU (0.46) | ALDH1A1NPC1S1PR1S1PR3KMT2A | |
| SCHEMBL15008177 | 0.75 | AGBL2 (0.41) | ALDH1A1NPC1UHRF1MAPTKDM4E | |
| SCHEMBL25366886 | 0.75 | NPC1 (0.49) | ALDH1A1NPC1EDNRAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4709722-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| WO-2024233547-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2024-11-14 | — | — | WO | disclosed |
| WO-2018086585-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND APPLICATIONS THEREOF | 山东罗欣药业集团股份有限公司 | 2018-05-17 | — | — | WO | disclosed |
| US-9751862-B2 | Pesticidally active substituted pyridyl carboxamides | SYNGENTA PARTICIPATIONS AG (CH) | 2017-09-05 | — | — | US | disclosed |
| US-9750253-B2 | Pesticidally active substituted pyridyl carboxamides | SYNGENTA PARTICIPATIONS AG (CH) | 2017-09-05 | — | — | US | disclosed |
| EP-3004110-B1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2017-07-26 | — | — | EP | disclosed |
| US-20170107200-A1 | PESTICIDALLY ACTIVE SUBSTITUTED PYRIDYL CARBOXAMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-04-20 | — | — | US | disclosed |
| EP-2984083-B1 | PESTICIDALLY ACTIVE SUBSTITUTED PYRIDYL CARBOXAMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-01-25 | — | — | EP | disclosed |
| EP-3004110-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | Novartis AG (CH) | 2016-04-13 | — | — | EP | disclosed |
| US-20160095843-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2016-04-07 | — | — | US | disclosed |
| US-20160095843-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2016-04-07 | — | — | US | disclosed |
| US-20160050924-A1 | PESTICIDALLY ACTIVE SUBSTITUTED PYRIDYL CARBOXAMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2016-02-25 | — | — | US | disclosed |
| EP-2984083-A1 | PESTICIDALLY ACTIVE SUBSTITUTED PYRIDYL CARBOXAMIDES | Syngenta Participations AG (CH) | 2016-02-17 | — | — | EP | disclosed |
| US-8975417-B2 | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2015-03-10 | — | — | US | disclosed |
| US-8975417-B2 | Pyrazolopyrrolidine derivatives and their use in the treatment of disease | NOVARTIS AG (CH) | 2015-03-10 | — | — | US | disclosed |
| WO-2014191896-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | NOVARTIS AG (CH) | 2014-12-04 | — | — | WO | disclosed |
| US-20140349990-A1 | Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease | NOVARTIS AG (CH) | 2014-11-27 | — | — | US | disclosed |
| US-20140349990-A1 | Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease | NOVARTIS AG (CH) | 2014-11-27 | — | — | US | disclosed |
| WO-2014166795-A1 | PESTICIDALLY ACTIVE SUBSTITUTED PYRIDYL CARBOXAMIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160050924-A1 | PESTICIDALLY ACTIVE SUBSTITUTED PYRIDYL CARBOXAMIDES | CBR3, CBR1, CYCS | ALDH1A1 2181/4885NPC1 3544/4885S1PR1 652/4885 |
| US-20160095843-A1 | PYRAZOLOPYRROLIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE | PKD1, PKD2, REN | ALDH1A1 777/4885NPC1 326/4885S1PR1 356/4885 |
| US-20140349990-A1 | Pyrazolopyrrolidine Derivatives and their Use in the Treatment of Disease | PKD1, PKD2, REN | ALDH1A1 766/4885NPC1 327/4885S1PR1 344/4885 |
| US-20170107200-A1 | PESTICIDALLY ACTIVE SUBSTITUTED PYRIDYL CARBOXAMIDES | CBR3, CBR1, CYCS | ALDH1A1 3242/4885NPC1 3642/4885S1PR1 1663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.