Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 10/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PDE9A | O76083 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16166256 | 0.83 | HPGD (0.43) | PTGDR2GPR139GAABRD4HPGD | |
| SCHEMBL25064660 | 0.81 | HPGD (0.44) | ALDH1A1HPGD | |
| SCHEMBL12377286 | 0.74 | ALDH1A1 (0.50) | DPP4DPP7ALDH1A1GAAHPGD | |
| SCHEMBL18290696 | 0.71 | PDE2A (0.49) | PDE2APTGDR2PDE9ABRD4 | |
| SCHEMBL18282858 | 0.71 | PDE2A (0.49) | PDE2APTGDR2PDE9ABRD4 | |
| SCHEMBL11483545 | 0.70 | CES2 (0.46) | PDE2APTGDR2CES2CES1PTGER4 | |
| SCHEMBL16166240 | 0.70 | PDE2A (0.44) | PDE2APDE9A | |
| SCHEMBL20150749 | 0.68 | PDE2A (0.52) | PDE2APTGDR2PDE9A | |
| SCHEMBL29092145 | 0.68 | PDE2A (0.44) | PDE2APTGDR2PDE9ABRD4 | |
| SCHEMBL29092133 | 0.68 | PDE2A (0.44) | PDE2APTGDR2PDE9ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167528-A1 | SPIROPYRAZOLOPYRIDINE DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF VIRAL INFECTIONS | NOVARTIS AG (CH) | 2014-10-16 | — | — | WO | disclosed |