Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14054369 | 0.85 | PTGES (0.42) | L3MBTL1MEN1KMT2ANPSR1DYRK1A | |
| SCHEMBL16166680 | 0.80 | KDM4E (0.43) | L3MBTL1ALDH1A1ALOX15KDM4ENPSR1 | |
| SCHEMBL5593053 | 0.80 | ALDH1A1 (0.47) | ALDH1A1ALOX15KDM4EMEN1KMT2A | |
| SCHEMBL509278 | 0.79 | CYP2C19 (0.51) | L3MBTL1ALDH1A1KDM4EKMT2ANPSR1 | |
| SCHEMBL506759 | 0.79 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL9370802 | 0.78 | KDM4E (0.50) | L3MBTL1ALDH1A1ALOX15KDM4EMEN1 | |
| SCHEMBL1205923 | 0.78 | TSHR (0.46) | L3MBTL1KDM4EMEN1KMT2ANPSR1 | |
| SCHEMBL12240461 | 0.76 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL24139848 | 0.75 | DYRK1A (0.50) | L3MBTL1KDM4ENPSR1DYRK1AMAPT | |
| SCHEMBL31432106 | 0.74 | MAPKAPK2 (0.45) | L3MBTL1DYRK1ANAMPTBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |
| WO-2014167444-A1 | SUBSTITUTED BICYCLIC COMPOUNDS AS mPGES-1 INHIBITORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2014-10-16 | — | — | WO | disclosed |