Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RHOC | P08134 | 2/20 | 0.38 |
| ▸ | RHOA | P61586 | 2/20 | 0.38 |
| ▸ | IDO1 | P14902 | 3/20 | 0.38 |
| ▸ | TDO2 | P48775 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015806 | 0.95 | TRPM8 (0.40) | EPHX2TRPM8 | |
| SCHEMBL16175678 | 0.92 | KDM4E (0.40) | MAPTNPSR1KDM4E | |
| SCHEMBL5014416 | 0.92 | TRPM8 (0.42) | EPHX2TRPM8SMN1; SMN2 | |
| SCHEMBL5012816 | 0.91 | FPR1 (0.40) | EPHX2TRPM8 | |
| SCHEMBL5014417 | 0.91 | TRPV1 (0.41) | EPHX2TRPM8MAPTSMN1; SMN2 | |
| SCHEMBL5011264 | 0.91 | TRPV1 (0.41) | EPHX2TRPM8 | |
| SCHEMBL16175670 | 0.91 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2NPSR1KDM4EUTS2R | |
| SCHEMBL5012223 | 0.91 | TRPV1 (0.41) | EPHX2TRPM8MAPTSMN1; SMN2 | |
| SCHEMBL5014559 | 0.91 | SMN1; SMN2 (0.41) | MAPTSMN1; SMN2NPSR1KDM4EUTS2R | |
| SCHEMBL5014396 | 0.91 | FAAH (0.41) | EPHX2TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |