Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 7/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 2/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015785 | 0.96 | FAAH (0.43) | FAAHTRPV1TRPM8EPHX2THRB | |
| SCHEMBL5015806 | 0.95 | TRPM8 (0.40) | FAAHTRPV1TRPM8EPHX2F2 | |
| SCHEMBL5015775 | 0.93 | FAAH (0.44) | FAAHTRPV1TRPM8EPHX2THRB | |
| SCHEMBL5011295 | 0.92 | MAPT (0.44) | FAAHTRPV1EPHX2MGLLNPC1 | |
| SCHEMBL5014416 | 0.91 | TRPM8 (0.42) | FAAHTRPV1TRPM8EPHX2RAB9A | |
| SCHEMBL5011264 | 0.91 | TRPV1 (0.41) | FAAHTRPV1TRPM8EPHX2F2 | |
| SCHEMBL5012223 | 0.91 | TRPV1 (0.41) | FAAHTRPV1TRPM8EPHX2NPC1 | |
| SCHEMBL5014417 | 0.91 | TRPV1 (0.41) | FAAHTRPV1TRPM8EPHX2NPC1 | |
| SCHEMBL16175698 | 0.91 | EPHX2 (0.43) | TRPM8EPHX2 | |
| SCHEMBL5012816 | 0.91 | FPR1 (0.40) | FAAHTRPV1TRPM8EPHX2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |