Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 4/20 | 0.39 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PYGL | P06737 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011113 | 0.90 | RAB9A (0.43) | ITGB1ITGA4FAAHRAB9AF10 | |
| SCHEMBL5012268 | 0.87 | KMT2A (0.42) | ITGB1ITGA4FAAHRAB9AF10 | |
| SCHEMBL5012891 | 0.87 | MAPT (0.45) | RAB9AF10F2PRSS1LMNA | |
| SCHEMBL5125301 | 0.86 | MAPT (0.47) | ITGB1ITGA4FAAHRAB9APYGL | |
| SCHEMBL16175610 | 0.86 | ALDH1A1 (0.39) | FAAHF10LMNAKMT2A | |
| SCHEMBL5012988 | 0.85 | SMN1; SMN2 (0.37) | FAAHRAB9AF10F2PRSS1 | |
| SCHEMBL5012914 | 0.84 | LMNA (0.40) | FAAHRAB9AF10F2PRSS1 | |
| SCHEMBL16175714 | 0.82 | HTT (0.46) | KMT2A | |
| SCHEMBL5012290 | 0.82 | F10 (0.43) | F10F2PRSS1KMT2A | |
| SCHEMBL5068349 | 0.81 | KMT2A (0.42) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |