Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16175610 | 0.92 | ALDH1A1 (0.39) | KMT2AFAAHLMNAF10SMN1; SMN2 | |
| SCHEMBL5011113 | 0.91 | RAB9A (0.43) | KMT2AITGB1ITGA4FAAHF10 | |
| SCHEMBL5012988 | 0.90 | SMN1; SMN2 (0.37) | KMT2AFAAHLMNAF10NPC1 | |
| SCHEMBL5012914 | 0.89 | LMNA (0.40) | KMT2AFAAHLMNAF10NPC1 | |
| SCHEMBL5068349 | 0.89 | KMT2A (0.42) | KMT2AMEN1ATM | |
| SCHEMBL5012280 | 0.89 | KMT2A (0.45) | KMT2AITGB1ITGA4F10F2 | |
| SCHEMBL16175594 | 0.89 | KDM4E (0.41) | KMT2AITGB1ITGA4MEN1SMN1; SMN2 | |
| SCHEMBL5011233 | 0.89 | KDM4E (0.41) | KMT2AITGB1ITGA4MEN1SMN1; SMN2 | |
| SCHEMBL5012899 | 0.89 | KMT2A (0.46) | KMT2ANPC1MEN1RAB9ASMN1; SMN2 | |
| SCHEMBL5012913 | 0.88 | KMT2A (0.44) | KMT2AITGB1ITGA4F10F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |