Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BBOX1 | O75936 | 9/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.38 |
| ▸ | CPT2 | P23786 | 1/20 | 0.35 |
| ▸ | CPT1A | P50416 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRAT | P43155 | 1/20 | 0.31 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL4618092 | 0.87 | TSHR (0.43) | TSHRBBOX1ALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL8651387 | 0.87 | TSHR (0.48) | TSHRBBOX1ALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL8678519 | 0.87 | TSHR (0.53) | TSHRBBOX1ALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL2803780 | 0.87 | TSHR (0.53) | TSHRBBOX1ALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL4900209 | 0.87 | — | — | |
| Betaine SCHEMBL31467313 | 0.87 | — | — | |
| Glycinebetaine SCHEMBL7739 | 0.87 | — | — | |
| Glycinebetaine SCHEMBL2520108 | 0.86 | LMNA (0.46) | TSHRBBOX1ALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL10425194 | 0.84 | TSHR (0.48) | TSHRBBOX1ALDH1A1LMNAAPEX1 | |
| Glycinebetaine SCHEMBL4255367 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5061383-A | NONTOXIC FIRE SUPPRESSANT | FRILOUX EDWARD E (US) | 1991-10-29 | — | — | US | claimed |
| US-8735446-B2 | Vanillin acetals and sensory stimulant composition containing the same | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2014-05-27 | — | — | US | disclosed |
| US-8632792-B2 | Cooling sensation agent composition and sensory stimulation agent composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2014-01-21 | — | — | US | disclosed |
| EP-1761238-B1 | MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION COMPRISING THE SAME | TAKASAGO PERFUMERY CO LTD (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-20120219512-A1 | VANILLIN ACETALS AND SENSORY STIMULANT COMPOSITION CONTAINING THE SAME | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-08-30 | — | — | US | disclosed |
| US-8236970-B2 | Vanillin acetals | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2012-08-07 | — | — | US | disclosed |
| US-20110117147-A1 | COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2011-05-19 | — | — | US | disclosed |
| US-7923585-B2 | Menthol derivative and cooling agent composition comprising the same | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2011-04-12 | — | — | US | disclosed |
| EP-1896557-B1 | FLAVOR AND FRAGRANCE COMPOSITION | TAKASAGO PERFUMERY CO LTD (JP) | 2010-05-05 | — | — | EP | disclosed |
| US-20090275669-A1 | Flavor and fragrance composition | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2009-11-05 | — | — | US | disclosed |
| US-20090208427-A1 | Vanillin Acetals and Sensory Stimulant Composition Containing the Same | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2009-08-20 | — | — | US | disclosed |
| EP-1902043-A1 | VANILLIN ACETALS AND SENSORY STIMULANT COMPOSITION CONTAINING THE SAME | Takasago International Corporation (JP) | 2008-03-26 | — | — | EP | disclosed |
| EP-1896557-A1 | FLAVOR AND FRAGRANCE COMPOSITION | Takasago International Corporation (JP) | 2008-03-12 | — | — | EP | disclosed |
| US-20070225378-A1 | Menthol Dearivative and Cooling Agent Composition Comprising the Same | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-09-27 | — | — | US | disclosed |
| EP-1761238-A1 | MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION COMPRISING THE SAME | Takasago International Corporation (JP) | 2007-03-14 | — | — | EP | disclosed |
| WO-2007004740-A1 | VANILLIN ACETALS AND SENSORY STIMULANT COMPOSITION CONTAINING THE SAME | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2007-01-11 | — | — | WO | disclosed |
| WO-2006137556-A1 | FLAVOR AND FRAGRANCE COMPOSITION | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2006-12-28 | — | — | WO | disclosed |
| WO-2005115325-A1 | MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION COMPRISING THE SAME | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2005-12-08 | — | — | WO | disclosed |
| EP-0689582-A1 | ACIDIC LIQUID DETERGENT COMPOSITIONS FOR BATHROOMS | THE PROCTER & GAMBLE COMPANY (US) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994021772-A1 | ACIDIC LIQUID DETERGENT COMPOSITIONS FOR BATHROOMS | THE PROCTER & GAMBLE COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110117147-A1 | COOLING SENSATION AGENT COMPOSITION AND SENSORY STIMULATION AGENT COMPOSITION | TRPA1, HRH1, HRH2 | TSHR 2479/4885BBOX1 1733/4885ALDH1A1 520/4885 |
| US-20120219512-A1 | VANILLIN ACETALS AND SENSORY STIMULANT COMPOSITION CONTAINING THE SAME | TRPA1, TRPV1, TAS2R5 | TSHR 4182/4885BBOX1 1805/4885ALDH1A1 70/4885 |
| US-20090208427-A1 | Vanillin Acetals and Sensory Stimulant Composition Containing the Same | TRPA1, TRPV1, TAS2R5 | TSHR 4182/4885BBOX1 1805/4885ALDH1A1 70/4885 |
| US-20070225378-A1 | Menthol Dearivative and Cooling Agent Composition Comprising the Same | TRPM7, TRPA1, TRPM2 | TSHR 3080/4885BBOX1 503/4885ALDH1A1 443/4885 |
| US-20090275669-A1 | Flavor and fragrance composition | TAS2R40, TAS2R1, TAS2R50 | TSHR 3954/4885BBOX1 1554/4885ALDH1A1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.