Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | AHR | P35869 | 2/20 | 0.38 |
| ▸ | TYMS | P04818 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ALPG | P10696 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16523329 | 0.83 | BACE1 (0.44) | KDM4EBACE1KMT2ACYP1A2CYP2A6 | |
| SCHEMBL31275 | 0.76 | CYP1A2 (0.50) | KDM4EBACE1KMT2ACYP1A2CYP2A6 | |
| SCHEMBL17696315 | 0.74 | TYMS (0.37) | TYMS | |
| SCHEMBL13423879 | 0.74 | KMT2A (0.52) | KDM4EKMT2ACYP3A4MAPTCASP1 | |
| SCHEMBL27348359 | 0.74 | — | — | |
| SCHEMBL25207842 | 0.74 | BACE1 (0.45) | KDM4EBACE1KMT2ACYP1A2CYP2A6 | |
| SCHEMBL16523332 | 0.74 | DYRK1A (0.48) | KDM4EBACE1ARKMT2ACYP1A2 | |
| SCHEMBL30758869 | 0.74 | ALDH1A1 (0.48) | KDM4EKMT2ACYP1A2PDE3BPDE3A | |
| SCHEMBL31317383 | 0.71 | CYP17A1 (0.39) | KDM4ECYP1A2NPC1CYP3A4MAPT | |
| SCHEMBL18066769 | 0.71 | ENPP2 (0.46) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4660199-A1 | 19-NOR NEUROACTIVE STEROIDS FOR INDUCING SEDATION | Sage Therapeutics, Inc. (US) | 2025-12-10 | — | — | EP | disclosed |
| US-20240239836-A9 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2024-07-18 | — | — | US | disclosed |
| US-20240239836-A9 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2024-07-18 | — | — | US | disclosed |
| EP-3719030-B1 | 19-NOR NEUROACTIVE STEROIDS FOR INDUCING SEDATION | SAGE THERAPEUTICS INC (US) | 2024-07-10 | — | — | EP | disclosed |
| EP-3719030-B1 | 19-NOR NEUROACTIVE STEROIDS FOR INDUCING SEDATION | SAGE THERAPEUTICS INC (US) | 2024-07-10 | — | — | EP | disclosed |
| US-20240025942-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240025942-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2024-01-25 | — | — | US | disclosed |
| US-20240025942-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. | 2024-01-25 | — | — | US | disclosed |
| CN-117304245-A | 19-nor steroids that stimulate neural activity and methods of use thereof | 萨奇治疗股份有限公司 | 2023-12-29 | — | — | CN | disclosed |
| US-20230279044-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS INC (US) | 2023-09-07 | — | — | US | disclosed |
| US-9365611-B2 | 19-NOR neuroactive steroids and methods of use thereof | SAGE THERAPEUTICS, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| US-9365611-B2 | 19-NOR neuroactive steroids and methods of use thereof | SAGE THERAPEUTICS, INC. (US) | 2016-06-14 | — | — | US | disclosed |
| WO-2016061527-A1 | COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS | SAGE THERAPEUTICS, INC. (US) | 2016-04-21 | — | — | WO | disclosed |
| US-20160083418-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2016-03-24 | — | — | US | disclosed |
| US-20160083418-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2016-03-24 | — | — | US | disclosed |
| US-20160083418-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. | 2016-03-24 | — | — | US | disclosed |
| WO-2014169832-A9 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2016-03-03 | — | — | WO | disclosed |
| EP-2986624-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | Sage Therapeutics, Inc. (US) | 2016-02-24 | — | — | EP | disclosed |
| WO-2015027227-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | SAGE THERAPEUTICS, INC. (US) | 2015-02-26 | — | — | WO | disclosed |
| WO-2014169832-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | SAGE THERAPEUTICS, INC. (US) | 2014-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239836-A9 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | ADRB2, TACR2, CNR1 | KDM4E 2129/4885BACE1 938/4885AR 141/4885 |
| US-20230279044-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | ADRB2, TACR2, CNR1 | KDM4E 2129/4885BACE1 938/4885AR 141/4885 |
| US-20160083418-A1 | 19-NOR NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF | NR3C2, HSD3B1, HSD3B2 | KDM4E 3165/4885BACE1 72/4885AR 624/4885 |
| US-20240025942-A1 | NEUROACTIVE STEROIDS, COMPOSITIONS, AND USES THEREOF | GABRR1, NR3C2, GABRA1 | KDM4E 2296/4885BACE1 891/4885AR 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.