Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.67 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.62 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.62 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16179842 | 0.90 | KMT2A (0.83) | SIRT6KMT2AMEN1SIRT3PKM | |
| SCHEMBL16179518 | 0.90 | SIRT6 (1.00) | SIRT6KMT2AMEN1SIRT3ALDH1A1 | |
| SCHEMBL30772317 | 0.84 | KMT2A (0.87) | SIRT6KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL27296254 | 0.84 | KMT2A (0.87) | SIRT6KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL13219807 | 0.81 | MAPT (0.80) | SIRT6KMT2AMEN1SIRT3PKM | |
| Benzoylpas SCHEMBL563122 | 0.81 | KMT2A (1.00) | SIRT6KMT2AMEN1PKMMAPT | |
| SCHEMBL15056399 | 0.81 | RAB9A (0.75) | SIRT6KMT2AMEN1PKMALDH1A1 | |
| SCHEMBL29564094 | 0.81 | MEN1 (1.00) | SIRT6KMT2AMEN1SIRT3ALDH1A1 | |
| SCHEMBL16179714 | 0.81 | MEN1 (1.00) | SIRT6KMT2AMEN1SIRT3ALDH1A1 | |
| Benzoylpas SCHEMBL9770542 | 0.80 | KMT2A (0.97) | SIRT6KMT2AMEN1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014170873-A1 | COMPOUNDS WITH A SIRTUIN INHIBITING ACTIVITY | UNIVERSITÀ DEGLI STUDI DI GENOVA (IT) | 2014-10-23 | — | — | WO | claimed |
| WO-2014170873-A1 | COMPOUNDS WITH A SIRTUIN INHIBITING ACTIVITY | UNIVERSITÀ DEGLI STUDI DI GENOVA (IT) | 2014-10-23 | — | — | WO | disclosed |