Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 5/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16176984 | 0.99 | PKM (0.56) | PKMIDO1PRCPCHRNA7TLR9 | |
| SCHEMBL21486288 | 0.77 | PKM (0.61) | PKMLMNA | |
| SCHEMBL21034172 | 0.77 | IDO1 (0.57) | IDO1CHRNA7TLR9TLR8TLR7 | |
| SCHEMBL24376403 | 0.76 | PKM (0.59) | PKMLMNA | |
| SCHEMBL7366882 | 0.76 | PKM (0.59) | PKMHRH4 | |
| SCHEMBL16188992 | 0.76 | PKM (0.59) | PKMDDAH1LMNA | |
| SCHEMBL13122022 | 0.75 | CHRNB2 (0.46) | TLR9TLR8TLR7 | |
| SCHEMBL21034157 | 0.75 | IDO1 (0.78) | IDO1PRCPCHRNA7 | |
| SCHEMBL21000937 | 0.75 | IDO1 (0.42) | IDO1CHRNA7LMNA | |
| SCHEMBL8327049 | 0.72 | PKM (0.55) | PKMIDO1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2987793-B1 | HETEROCYCLIC ACETIC ACID AMIDE COMPOUND | ASTELLAS PHARMA INC (JP) | 2017-10-25 | — | — | EP | disclosed |
| US-9708307-B2 | Heterocyclic acetamide compound | ASTELLAS PHARMA INC. (JP) | 2017-07-18 | — | — | US | disclosed |
| US-20150045402-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2015-02-12 | — | — | US | disclosed |
| US-8937087-B2 | Heterocyclic acetamide compound | ASTELLAS PHARMA INC. (JP) | 2015-01-20 | — | — | US | disclosed |
| WO-2014171528-A1 | HETEROCYCLIC ACETIC ACID AMIDE COMPOUND | アステラス製薬株式会社 (JP) | 2014-10-23 | — | — | WO | disclosed |
| US-20140315963-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140315963-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | DRD1, DRD2, OPRD1 | PKM 2819/4885IDO1 2135/4885PRCP 4251/4885 |
| US-20150045402-A1 | HETEROCYCLIC ACETAMIDE COMPOUND | DRD2, DRD1, OPRD1 | PKM 2958/4885IDO1 2202/4885PRCP 4315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.