Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.30 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28558507 | 0.89 | ARG1 (0.35) | DPP4DPP8DPP9CHRNB2CHRNB4 | |
| SCHEMBL16192183 | 0.89 | ARG1 (0.35) | DPP4DPP8DPP9CHRNB2CHRNB4 | |
| SCHEMBL28558506 | 0.89 | ARG1 (0.35) | DPP4DPP8DPP9CHRNB2CHRNB4 | |
| SCHEMBL16191794 | 0.88 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL16191914 | 0.81 | JAK2 (0.33) | HSD11B1DPP4DPP8DPP9 | |
| SCHEMBL30832718 | 0.78 | HSD11B1 (0.44) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16191776 | 0.78 | NR1H2 (0.56) | HSD11B1 | |
| SCHEMBL16191779 | 0.78 | NR1H2 (0.56) | HSD11B1 | |
| SCHEMBL23290986 | 0.77 | CHRM1 (0.33) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL23290987 | 0.77 | CHRM1 (0.33) | HSD11B1CHRNB2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-10-01 | — | — | US | disclosed |
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-02-16 | — | — | US | disclosed |
| US-9527851-B2 | Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-12-27 | — | — | US | disclosed |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2014-11-13 | — | — | US | disclosed |
| EP-2796460-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | DHFR, PPOX, PAH | HSD11B1 401/4885DPP4 2052/4885DPP8 1859/4885 |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JAK2, JAK1, JAK3 | HSD11B1 3278/4885DPP4 2654/4885DPP8 2568/4885 |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JAK1, JAK3, JAK2 | HSD11B1 526/4885DPP4 1428/4885DPP8 1406/4885 |
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | DHFR, PPOX, PAH | HSD11B1 401/4885DPP4 2052/4885DPP8 1859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.