Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28558506 | 1.00 | ARG1 (0.35) | ARG1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL28558507 | 1.00 | ARG1 (0.35) | ARG1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16192066 | 0.89 | HSD11B1 (0.32) | CHRNB2CHRNB4CHRNA3CHRNA4DPP4 | |
| SCHEMBL16191914 | 0.87 | JAK2 (0.33) | GRIN2BDPP4DPP8DPP9 | |
| SCHEMBL4042893 | 0.82 | — | — | |
| SCHEMBL31560430 | 0.82 | NR1H2 (0.32) | ARG1NR1H2 | |
| SCHEMBL1439352 | 0.79 | — | — | |
| SCHEMBL26918602 | 0.79 | — | — | |
| SCHEMBL28453777 | 0.79 | NR1H2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4GRIN2B | |
| SCHEMBL16191794 | 0.77 | HSD11B1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-10-01 | — | — | US | disclosed |
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-02-16 | — | — | US | disclosed |
| US-9527851-B2 | Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-12-27 | — | — | US | disclosed |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2014-11-13 | — | — | US | disclosed |
| EP-2796460-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | DHFR, PPOX, PAH | ARG1 2146/4885CHRNB2 4794/4885CHRNB4 4812/4885 |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JAK2, JAK1, JAK3 | ARG1 2148/4885CHRNB2 4843/4885CHRNB4 4849/4885 |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JAK1, JAK3, JAK2 | ARG1 1403/4885CHRNB2 4885/4885CHRNB4 4880/4885 |
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | DHFR, PPOX, PAH | ARG1 2146/4885CHRNB2 4794/4885CHRNB4 4812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.