SCHEMBL16196249

SCHEMBL16196249

Nc1ncccc1-c1ccccc1O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 2/20 0.47
MKNK2 Q9HBH9 2/20 0.47
MAP4K4 O95819 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
RIPK1 Q13546 1/20 0.45
PDE5A O76074 1/20 0.45
CDK1 P06493 1/20 0.45
CDK2 P24941 1/20 0.45
NOS3 P29474 1/20 0.43
NOS1 P29475 1/20 0.43
NOS2 P35228 1/20 0.43
BRD4 O60885 1/20 0.43
NR1I2 O75469 1/20 0.43
SMARCA2 P51531 1/20 0.43
SMARCA4 P51532 1/20 0.43
PBRM1 Q86U86 1/20 0.43
IDO1 P14902 3/20 0.42
NAPRT Q6XQN6 1/20 0.42
PIK3CD O00329 1/20 0.41
PIK3CA P42336 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10062975 0.84 MAP4K4 (0.59) MKNK1MKNK2MAP4K4SMN1; SMN2CDK1
SCHEMBL30968134 0.82 MAP4K4 (0.57) MKNK1MKNK2MAP4K4SMN1; SMN2CDK1
SCHEMBL33700 0.80
SCHEMBL29358060 0.80
SCHEMBL4870156 0.80 NOS3 (0.52) MKNK1MKNK2MAP4K4NOS3NOS1
SCHEMBL30046325 0.78 ALDH1A1 (0.59) MKNK1MKNK2MAP4K4SMN1; SMN2CDK1
SCHEMBL29594708 0.78 RIPK1 (0.47) SMN1; SMN2RIPK1PDE5ACDK1IDO1
SCHEMBL28545758 0.78 RIPK1 (0.47) SMN1; SMN2RIPK1PDE5ACDK1IDO1
SCHEMBL28907433 0.78 ALDH1A1 (0.59) MKNK1MKNK2MAP4K4SMN1; SMN2CDK1
Hydrochloric Acid SCHEMBL11635965 0.78

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1264498-C Primary intermediates for oxidative dyeing of hair PROCTER & GAMBLE (US) 2006-07-19 CN claimed
CN-1239467-C Primary intermediates for oxidative dyeing of hair P & G CLAIROL INC (US) 2006-02-01 CN claimed
CN-1229100-C Primary intermediates for oxidative dyeing of hair P & G CLAIROL INC (US) 2005-11-30 CN claimed
CN-1229102-C Novel couplers for oxidative hair dyeing P & G CLAIROL INC (US) 2005-11-30 CN claimed
CN-1219501-C Primary intermediates for oxidative dyeing of hair P & G CLAIROL INCORP (US) 2005-09-21 CN claimed
CN-1213722-C Couplers for oxidative hair dyeing P & G CLAIROL INC (US) 2005-08-10 CN claimed
CN-1198574-C Novel couplers for oxidative hair dyeing P & G CLAIROL INC (US) 2005-04-27 CN claimed
CN-1607935-A Primary intermediates for oxidative dyeing of hair PROCTER & GAMBLE (US) 2005-04-20 CN claimed
CN-1503657-A Novel couplers for oxidative hair dyeing P&G 2004-06-09 CN claimed
CN-1501792-A Novel couplers for oxidative hair dyeing P&G克莱罗尔公司 2004-06-02 CN claimed
CN-1487819-A Primary intermediates for oxidative dyeing of hair P&G 2004-04-07 CN claimed
CN-1486170-A Novel couplers for use in oxidative hair dyeing P&G 2004-03-31 CN claimed
CN-1486297-A Primary intermediates for oxidative dyeing of hair P&G 2004-03-31 CN claimed
CN-1486172-A Primary intermediates for oxidative dyeing of hair P&G 2004-03-31 CN claimed
CN-1486171-A Couplers for oxidative hair dyeing P&G克莱罗尔公司 2004-03-31 CN claimed
CN-1477947-A Primary intermediates for oxidative dyeing of hair P&G 2004-02-25 CN claimed
CN-1474680-A Novel couplers for oxidative hair dyeing P&G克莱罗尔公司 2004-02-11 CN claimed
CN-1474679-A Novel couplers for oxidative hair dyeing P&G 2004-02-11 CN claimed
CN-1474681-A Novel couplers for oxidative hair dyeing P&G克莱罗尔公司 2004-02-11 CN claimed
CN-1449276-A Primary intermediates for oxidative dyeing of hair P & G CLAIROL INC (US) 2003-10-15 CN claimed