Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 3/20 | 0.49 |
| ▸ | NNMT | P40261 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4771472 | 0.75 | KDM4E (0.67) | NNMTSMN1; SMN2KDM4EALDH1A1ALOX15 | |
| SCHEMBL22401242 | 0.72 | NNMT (0.42) | HCAR3NNMTSMN1; SMN2KDM4EEPHX2 | |
| SCHEMBL5374100 | 0.71 | KDM4E (0.43) | HCAR3SMN1; SMN2KDM4EALDH1A1HSD17B10 | |
| SCHEMBL12874146 | 0.71 | CRHR1 (0.40) | HCAR3SMN1; SMN2ALDH1A1HSD17B10MAPT | |
| SCHEMBL17101820 | 0.71 | NNMT (0.45) | NNMTSMN1; SMN2KDM4EEPHX2PARP10 | |
| SCHEMBL7257903 | 0.70 | HCAR3 (0.37) | HCAR3SMN1; SMN2MAPT | |
| SCHEMBL3121440 | 0.70 | KDM4E (0.46) | NNMTSMN1; SMN2KDM4EALDH1A1ALOX15 | |
| SCHEMBL14852700 | 0.70 | HCAR3 (0.75) | HCAR3NNMTSMN1; SMN2KDM4EEPHX2 | |
| SCHEMBL3353364 | 0.70 | HCAR3 (0.48) | HCAR3KDM4EHSD17B10PARP10AOC3 | |
| SCHEMBL13701705 | 0.69 | KCNA5 (0.44) | HCAR3SMN1; SMN2TSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190287-B1 | TARTRATE SALTS OR COMPLEXES OF QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS INC (US) | 2014-10-29 | — | — | EP | disclosed |