Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.39 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200058 | 0.85 | HSD11B1 (0.40) | MEN1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL14039900 | 0.80 | ALDH1A1 (0.50) | MEN1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL7524976 | 0.77 | CYP1A2 (0.39) | MEN1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL14139212 | 0.76 | POLB (0.40) | CYP1A2CYP2C19GABRPGABRDGABRA1 | |
| SCHEMBL8569766 | 0.75 | HSD11B1 (0.47) | MEN1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL13682912 | 0.75 | NPC1 (0.41) | CYP1A2KDM4EALDH1A1 | |
| SCHEMBL8566222 | 0.73 | MEN1 (0.38) | MEN1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL16200053 | 0.72 | SLC34A1 (0.44) | PTGS1PTGS2 | |
| SCHEMBL16200057 | 0.72 | MAPK14 (0.42) | MEN1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL14039556 | 0.72 | NT5E (0.41) | CYP1A2PTGS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |