Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 4/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 9/20 | 0.36 |
| ▸ | SRC | P12931 | 4/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.35 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14039900 | 0.85 | ALDH1A1 (0.50) | ALDH1A1MAPTHTTKDM4EMEN1 | |
| SCHEMBL16200053 | 0.84 | SLC34A1 (0.44) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL16200054 | 0.82 | P2RX7 (0.45) | ALDH1A1NPC1RAB9AKDM4ECYP1A2 | |
| SCHEMBL16200062 | 0.80 | PTGS2 (0.46) | ALDH1A1NPC1MAPTRAB9AKDM4E | |
| SCHEMBL8108697 | 0.77 | SLC34A1 (0.38) | ALDH1A1MAPTKDM4EMEN1CYP1A2 | |
| SCHEMBL14039556 | 0.77 | NT5E (0.41) | ALDH1A1MAPTHTTKDM4ECYP1A2 | |
| SCHEMBL16200055 | 0.76 | MAPK14 (0.43) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL13683098 | 0.74 | KIF11 (0.39) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL13682912 | 0.74 | NPC1 (0.41) | ALDH1A1NPC1RAB9AKDM4ECYP1A2 | |
| SCHEMBL16200046 | 0.72 | MEN1 (0.41) | ALDH1A1KDM4EMEN1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |