Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200046 | 0.85 | MEN1 (0.41) | HSD11B1MEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8569766 | 0.84 | HSD11B1 (0.47) | HSD11B1MAPTMEN1CYP1A2CYP2C9 | |
| SCHEMBL16200051 | 0.81 | PTGS2 (0.39) | HSD11B1MAPTMBNL1TP53ADORA2A | |
| SCHEMBL16200388 | 0.80 | THRB (0.45) | HSD11B1MAPTPDE10AKMT2AMBNL1 | |
| SCHEMBL14039900 | 0.80 | ALDH1A1 (0.50) | MAPTMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8566222 | 0.79 | MEN1 (0.38) | HSD11B1MAPTPDE10AMEN1CYP1A2 | |
| SCHEMBL27321857 | 0.78 | HSD11B1 (0.43) | HSD11B1MAPTMEN1CYP1A2CYP2C9 | |
| SCHEMBL13738167 | 0.77 | MAPT (0.40) | HSD11B1MAPTMEN1KMT2AMBNL1 | |
| SCHEMBL8570221 | 0.77 | MEN1 (0.37) | HSD11B1PDE10AMEN1CYP1A2CYP2C9 | |
| SCHEMBL8565103 | 0.77 | MEN1 (0.37) | HSD11B1MEN1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |