Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A1 | Q06495 | 7/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14039900 | 0.85 | ALDH1A1 (0.50) | SLC34A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL16200057 | 0.84 | MAPK14 (0.42) | MAPK14MAPK13CSNK1DCSNK1EMAPK12 | |
| SCHEMBL16200062 | 0.83 | PTGS2 (0.46) | SMN1; SMN2PTGS2MAPTPOLBPTGS1 | |
| SCHEMBL14039556 | 0.83 | NT5E (0.41) | PTGS2MAPTPDE7A | |
| SCHEMBL8108697 | 0.80 | SLC34A1 (0.38) | SLC34A1SMN1; SMN2MAPT | |
| SCHEMBL20074876 | 0.77 | MAPK14 (0.59) | SLC34A1MAPK14SMN1; SMN2P2RX7MAPK13 | |
| SCHEMBL16200054 | 0.76 | P2RX7 (0.45) | SMN1; SMN2P2RX7PTGS2PTGS1RAB9A | |
| SCHEMBL14039836 | 0.75 | MAPK14 (0.43) | SLC34A1MAPK14P2RX7MAPK13CSNK1D | |
| SCHEMBL16200058 | 0.75 | HSD11B1 (0.40) | MAPTPOLB | |
| SCHEMBL8168903 | 0.74 | PTGS1 (0.38) | SMN1; SMN2PTGS2MAPTPOLBPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |