Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SLC34A1 | Q06495 | 3/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.31 |
| ▸ | RELA | Q04206 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200083 | 0.80 | ALDH1A1 (0.48) | ALDH1A1LMNAKDM4EP2RX7 | |
| SCHEMBL16200256 | 0.76 | L3MBTL1 (0.45) | SMN1; SMN2ALDH1A1LMNAKDM4ESLC34A1 | |
| SCHEMBL16200223 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2ALDH1A1LMNASLC34A1RAB9A | |
| SCHEMBL16200254 | 0.74 | MEN1 (0.47) | SMN1; SMN2ALDH1A1LMNASLC34A1RAB9A | |
| SCHEMBL16200248 | 0.73 | ALDH1A1 (0.40) | SMN1; SMN2ALDH1A1LMNAADORA2AADORA2B | |
| SCHEMBL13066526 | 0.73 | SLC34A1 (0.51) | SLC34A1 | |
| SCHEMBL13683160 | 0.71 | PIK3CD (0.46) | SMN1; SMN2ALDH1A1LMNASLC34A1RAB9A | |
| SCHEMBL16200081 | 0.70 | BACE1 (0.45) | SMN1; SMN2ALDH1A1LMNAKDM4ERAB9A | |
| SCHEMBL16200236 | 0.70 | LMNA (0.44) | SMN1; SMN2ALDH1A1LMNAKDM4ESLC34A1 | |
| SCHEMBL14062350 | 0.69 | BRD4 (0.44) | LMNAADORA2AADORA2BMAPTPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |