Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178815 | 0.84 | PGK1 (0.41) | PGK1GSK3BMAP4K2GAAKDM4E | |
| SCHEMBL13683103 | 0.82 | CYP2D6 (0.47) | GAAALDH1A1NPC1POLBGFER | |
| SCHEMBL16200317 | 0.81 | LMNA (0.39) | KDM4EALDH1A1LMNA | |
| SCHEMBL16200314 | 0.81 | ALDH1A1 (0.38) | GAAALDH1A1LMNANPC1POLB | |
| SCHEMBL16200318 | 0.76 | ACACB (0.43) | KDM4EALDH1A1LMNANPC1TAS1R3 | |
| SCHEMBL16200302 | 0.75 | GAA (0.41) | GAAALDH1A1LMNANPC1POLB | |
| SCHEMBL13178807 | 0.75 | GAA (0.46) | GAALMNANPC1POLBGFER | |
| SCHEMBL16200299 | 0.74 | SMN1; SMN2 (0.41) | GAAKDM4EALDH1A1LMNA | |
| SCHEMBL13178817 | 0.72 | GLA (0.41) | GAAALDH1A1LMNANPC1POLB | |
| SCHEMBL13178784 | 0.71 | GAA (0.46) | GAAKDM4EALDH1A1LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |