Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13178791 | 0.86 | P2RX3 (0.38) | LMNAHTR2AHTR2CALDH1A1TSHR | |
| SCHEMBL16200313 | 0.81 | PGK1 (0.41) | LMNAALDH1A1KDM4E | |
| SCHEMBL16200299 | 0.77 | SMN1; SMN2 (0.41) | LMNAHTR2AHTR2CALDH1A1TSHR | |
| SCHEMBL13683103 | 0.76 | CYP2D6 (0.47) | HTR2AALDH1A1 | |
| SCHEMBL16200314 | 0.75 | ALDH1A1 (0.38) | LMNAALDH1A1TSHRHTTMEN1 | |
| SCHEMBL16200318 | 0.70 | ACACB (0.43) | LMNAALDH1A1HTTMAPTKDM4E | |
| SCHEMBL13178807 | 0.70 | GAA (0.46) | LMNAHTT | |
| SCHEMBL16200302 | 0.70 | GAA (0.41) | LMNAALDH1A1TSHRMAPTMAPK1 | |
| SCHEMBL13178792 | 0.69 | CYP2D6 (0.44) | HTR2AALDH1A1TSHRHTTMAPT | |
| SCHEMBL13178817 | 0.67 | GLA (0.41) | LMNAHTR2AALDH1A1TSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |