Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 9/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NMT1 | P30419 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200403 | 0.83 | MC4R (0.41) | LMNANMT1MEN1KMT2ATDP1 | |
| SCHEMBL16200064 | 0.81 | CYP2A13 (0.42) | CXCR4MEN1KMT2AHRH3 | |
| SCHEMBL13184133 | 0.74 | SIGMAR1 (0.39) | SIGMAR1CXCR4LMNANMT1MEN1 | |
| SCHEMBL25146239 | 0.74 | L3MBTL1 (0.46) | SIGMAR1CXCR4LMNANMT1MEN1 | |
| SCHEMBL16200050 | 0.71 | PDE10A (0.42) | SIGMAR1NMT1CHRM2CHRM1POLB | |
| SCHEMBL30655795 | 0.68 | LMNA (0.43) | SIGMAR1CXCR4LMNAMEN1CHRM2 | |
| SCHEMBL27568633 | 0.68 | LMNA (0.43) | SIGMAR1CXCR4LMNAMEN1CHRM2 | |
| SCHEMBL13184159 | 0.67 | POLB (0.39) | LMNAKMT2APOLB | |
| SCHEMBL17127620 | 0.67 | SIGMAR1 (0.39) | SIGMAR1NMT1MEN1KMT2AHRH3 | |
| SCHEMBL16200226 | 0.66 | SIGMAR1 (0.40) | SIGMAR1CXCR4LMNAMEN1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |