Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | NMT1 | P30419 | 3/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 4/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.35 |
| ▸ | HTR3B | O95264 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | NMT2 | O60551 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13184422 | 0.79 | POLB (0.37) | POLBCHRM3 | |
| SCHEMBL18282504 | 0.72 | ALDH1A1 (0.43) | PDE10ACHRNB2CHRNA4HTR2CADRB1 | |
| SCHEMBL16200076 | 0.71 | CHRNB2 (0.45) | PDE10ACHRNB2CHRNA4ADRB2NMT1 | |
| SCHEMBL16200399 | 0.71 | SIGMAR1 (0.39) | POLBNMT1CHRM2CHRM1SIGMAR1 | |
| SCHEMBL31652344 | 0.70 | PDE10A (0.37) | PDE10AHTR2CADRB1 | |
| SCHEMBL18282489 | 0.70 | GUSB (0.33) | PDE10AHTR2CNMT1ADRB1 | |
| SCHEMBL18282515 | 0.70 | NMT1 (0.33) | HTR2CNMT1 | |
| SCHEMBL18282616 | 0.68 | ALDH1A1 (0.43) | — | |
| SCHEMBL18282502 | 0.68 | PKM (0.38) | PDE10AHTR2C | |
| SCHEMBL1781299 | 0.68 | DPP4 (0.41) | HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720545-B1 | BICYCLIC AND BRIDGED NITROGEN HETEROCYCLES | CHEMOCENTRYX INC (US) | 2014-10-29 | — | — | EP | disclosed |