SCHEMBL16200908

SCHEMBL16200908

Fc1ccc2c(c1)-c1cccc3cccc-2c13

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.58
HSD17B10 Q99714 5/20 0.58
MAPK1 P28482 4/20 0.58
TSHR P16473 4/20 0.58
L3MBTL1 Q9Y468 3/20 0.58
ATM Q13315 3/20 0.58
HPGD P15428 4/20 0.58
CASP1 P29466 3/20 0.58
CASP7 P55210 2/20 0.58
HIF1A Q16665 2/20 0.58
TP53 P04637 1/20 0.58
CYP3A4 P08684 2/20 0.47
PABPC1 P11940 1/20 0.47
DNMT1 P26358 1/20 0.47
CYP1A2 P05177 2/20 0.43
CYP2A6 P11509 1/20 0.43
CES2 O00748 1/20 0.43
BCHE P06276 1/20 0.43
CES1 P23141 1/20 0.43
MCL1 Q07820 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7555107 0.83 ALDH1A1 (0.65) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
SCHEMBL9856229 0.81 GPR3 (0.54) L3MBTL1ATMCYP1A2CYP2A6GPR3
SCHEMBL13645544 0.80 ALDH1A1 (0.61) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
SCHEMBL12887889 0.79 CYP1A2 (0.61) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
SCHEMBL23525587 0.75 ALDH1A1 (1.00) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
Fluoranthene SCHEMBL8873541 0.75 ALDH1A1 (1.00) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
Fluoranthene SCHEMBL29355720 0.75 ALDH1A1 (1.00) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
Fluoranthene SCHEMBL29396242 0.75 ALDH1A1 (1.00) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
Fluoranthene SCHEMBL27152 0.75 ALDH1A1 (1.00) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1
SCHEMBL15960556 0.75 ALDH1A1 (0.48) ALDH1A1HSD17B10MAPK1TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9298115-B2 Electrophotographic photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-03-29 US disclosed
US-9298115-B2 Electrophotographic photosensitive member, method for manufacturing electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2016-03-29 US disclosed
US-20140322637-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2014-10-30 US disclosed
US-20140322637-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD FOR MANUFACTURING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2014-10-30 US disclosed