Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.39 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 6/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 6/20 | 0.37 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 2/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | HEXA | P06865 | 1/20 | 0.33 |
| ▸ | HEXB | P07686 | 1/20 | 0.33 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.33 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16201194 | 0.89 | PRMT6 (0.51) | PRMT6PRMT8PIM1PIM3PRMT1 | |
| SCHEMBL16125844 | 0.87 | PRMT6 (0.41) | PRMT6PRMT8DRD2PRMT1PRMT3 | |
| SCHEMBL16201340 | 0.85 | TDO2 (0.33) | DRD2PIM1PIM3PIM2DYRK1A | |
| SCHEMBL16201364 | 0.85 | PRMT6 (0.44) | PRMT6PIM1PIM3PRMT1PIM2 | |
| SCHEMBL16201380 | 0.83 | CRHR1 (0.36) | PRMT6PRMT8DRD2PRMT1PRMT3 | |
| SCHEMBL16201339 | 0.81 | PRMT6 (0.38) | PRMT6PRMT8DRD2PRMT1PRMT3 | |
| SCHEMBL16201371 | 0.81 | NPSR1 (0.39) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201384 | 0.80 | PRMT3 (0.40) | PRMT6PRMT8PRMT1PRMT3CARM1 | |
| SCHEMBL16201349 | 0.80 | HRH3 (0.43) | DRD2PIM1PIM3PIM2KDM1A | |
| SCHEMBL16201425 | 0.79 | AGTR1 (0.35) | PRMT6PRMT8PRMT1PRMT3CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346761-B2 | Arginine methyltransferase inhibitors and uses thereof | Epizyme, Inc. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323537-A1 | ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF | PRMT1, PRMT3, PRMT5 | PRMT6 4/4885PRMT8 6/4885DRD2 4718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.