Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TLR4 | O00206 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1620557 | 0.84 | CA1 (0.39) | ALDH1A1 | |
| SCHEMBL8907794 | 0.83 | CYSLTR2 (0.31) | — | |
| SCHEMBL5383978 | 0.81 | CA1 (0.39) | ALDH1A1 | |
| SCHEMBL1010833 | 0.77 | CA2 (0.41) | ALDH1A1LMNA | |
| SCHEMBL7281736 | 0.75 | HTT (0.31) | — | |
| SCHEMBL3798221 | 0.74 | ALDH1A1 (0.47) | ALDH1A1GAALMNATLR4 | |
| SCHEMBL7539413 | 0.70 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL7281044 | 0.69 | HSP90AA1 (0.42) | ALDH1A1LMNA | |
| SCHEMBL8766895 | 0.69 | — | — | |
| SCHEMBL6902430 | 0.69 | ERN1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194046-B1 | Triazolone derivative | EISAI R&D MAN CO LTD (JP) | 2012-05-09 | — | — | EP | disclosed |
| US-8163787-B2 | Triazolone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20110112109-A1 | TRIAZOLONE DERIVATIVES | CLARK RICHARD | 2011-05-12 | — | — | US | disclosed |
| US-7928228-B2 | Triazolone derivatives | EISAI CO., LTD. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-7816522-B2 | Triazolone derivatives | EISAI CO., LTD. (JP) | 2010-10-19 | — | — | US | disclosed |
| US-20100190783-A1 | TRIAZOLONE DERIVATIVES | CLARK RICHARD | 2010-07-29 | — | — | US | disclosed |
| EP-2194046-A1 | Triazolone derivative | Eisai R&D Management Co., Ltd. (JP) | 2010-06-09 | — | — | EP | disclosed |
| EP-2000465-A1 | TRIAZOLONE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2008-12-10 | — | — | EP | disclosed |
| US-20080015199-A1 | Triazolone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-01-17 | — | — | US | disclosed |
| EP-1482953-A4 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS INC (US) | 2006-12-13 | — | — | EP | disclosed |
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | PHAN HIEU T (CH) | 2005-06-09 | — | — | US | disclosed |
| EP-1482953-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | Ilex Products, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003068240-A1 | ALPHA-SUBSTITUTED HETEROARYLALKYL PHOSPHONATE DERIVATTIVES | ILEX PRODUCTS, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190783-A1 | TRIAZOLONE DERIVATIVES | H1-0, H1-10, H1-2 | ALDH1A1 701/4885GAA 4240/4885LMNA 2146/4885 |
| US-20110112109-A1 | TRIAZOLONE DERIVATIVES | H1-10, H1-0, H1-2 | ALDH1A1 905/4885GAA 4263/4885LMNA 1872/4885 |
| US-20050124581-A1 | Alpha-substituted heteroarylalkyl phosphonate derivatives | APOB, APOL1, LDLR | ALDH1A1 2919/4885GAA 682/4885LMNA 276/4885 |
| US-20080015199-A1 | Triazolone derivatives | F3, F12, F2 | ALDH1A1 710/4885GAA 3903/4885LMNA 1245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.