Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 7/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL862858 | 1.00 | ALDH1A1 (0.38) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL1619623 | 0.87 | ALDH1A1 (0.39) | ALDH1A1GAAKDRDPP4EGFR | |
| SCHEMBL863038 | 0.87 | ALDH1A1 (0.39) | ALDH1A1GAAKDRDPP4EGFR | |
| SCHEMBL858362 | 0.87 | KDM4E (0.35) | ALDH1A1KDREGFRKDM4ESMN1; SMN2 | |
| SCHEMBL858364 | 0.87 | KDM4E (0.35) | ALDH1A1KDREGFRKDM4ESMN1; SMN2 | |
| SCHEMBL862853 | 0.86 | MAPKAPK2 (0.39) | CYP1A2CYP3A4CYP2C9CYP2C19KDR | |
| SCHEMBL1684000 | 0.84 | KDR (0.38) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL18175977 | 0.84 | KDR (0.38) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL28801538 | 0.78 | POLB (0.39) | ALDH1A1GAACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL12067848 | 0.74 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338596-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20120088913-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2012-04-12 | — | — | US | disclosed |
| US-20110295003-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110295003-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | PAH, AZI2, ABL2 | ALDH1A1 341/4885GAA 703/4885CYP1A2 131/4885 |
| US-20120088913-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | PAH, AZI2, ABL2 | ALDH1A1 341/4885GAA 703/4885CYP1A2 131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.