Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | ATF1 | P18846 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | JUN | P05412 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL858364 | 1.00 | KDM4E (0.35) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL1621164 | 0.87 | ALDH1A1 (0.38) | KDM4EALDH1A1SMN1; SMN2EGFRKDR | |
| SCHEMBL862858 | 0.87 | ALDH1A1 (0.38) | KDM4EALDH1A1SMN1; SMN2EGFRKDR | |
| SCHEMBL14300707 | 0.84 | KMT2A (0.40) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL23924759 | 0.78 | EGFR (0.46) | KDM4EALDH1A1SMN1; SMN2NFKB1ATF1 | |
| SCHEMBL12067848 | 0.76 | ALDH1A1 (0.43) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL862853 | 0.74 | MAPKAPK2 (0.39) | KDM4ESMN1; SMN2KMT2AMEN1EGFR | |
| SCHEMBL863038 | 0.73 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2EGFRKDR | |
| SCHEMBL1619623 | 0.73 | ALDH1A1 (0.39) | KDM4EALDH1A1SMN1; SMN2EGFRKDR | |
| SCHEMBL18175977 | 0.72 | KDR (0.38) | KDM4EALDH1A1SMN1; SMN2EGFRKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2851367-B1 | PROCESS FOR THE PREPARATION OF A 2-AMINO-5,8-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDINE BY REACTION OF A 5-HALO-8-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-2-AMINE WITH AN ALKALI METAL ALKOXIDE IN AN ALCOHOLIC SOLVENT | DOW AGROSCIENCES LLC (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2576558-B9 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2015-07-08 | — | — | EP | disclosed |
| EP-2851367-A1 | Process for the preparation of a 2-amino-5,8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidine by reaction of a 5-halo-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amine with an alkali metal alkoxide in an alcoholic solvent | Dow AgroSciences LLC (US) | 2015-03-25 | — | — | EP | disclosed |
| EP-2576558-B1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2014-12-24 | — | — | EP | disclosed |
| EP-2576558-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-2-AMINES | Dow AgroSciences LLC (US) | 2013-04-10 | — | — | EP | disclosed |
| US-8338596-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20120088913-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2012-04-12 | — | — | US | disclosed |
| US-8143395-B2 | Process for the preparation of 5-substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines | DOW AGROSCIENCES LLC (US) | 2012-03-27 | — | — | US | disclosed |
| WO-2011149861-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-C]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2011-12-01 | — | — | WO | disclosed |
| US-20110295003-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | DOW AGROSCIENCES LLC (US) | 2011-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110295003-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | PAH, AZI2, ABL2 | KDM4E 561/4885ALDH1A1 341/4885SMN1; SMN2 1156/4885 |
| US-20120088913-A1 | PROCESS FOR THE PREPARATION OF 5-SUBSTITUTED-8-ALKOXY[1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-2-AMINES | PAH, AZI2, ABL2 | KDM4E 561/4885ALDH1A1 341/4885SMN1; SMN2 1156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.